THIOL FUNCTIONALIZED GOLD NANOBIPYRAMIDS-BASED PLASMONIC SENSOR FOR GLUCOSE DETECTION

Natasya Salsabiila; Marlia Morsin; Muhammad Hanif Hasbullah; Suratun Nafisah; Nur Liyana Razali; Iwantono

doi:10.31436/iiumej.v25i1.2811

Authors

Natasya Salsabiila Universiti Tun Hussein Onn Malaysia https://orcid.org/0009-0001-9772-5010
Marlia Morsin Universiti Tun Hussein Onn Malaysia https://orcid.org/0000-0002-5351-7826
Muhammad Hanif Hasbullah Universiti Tun Hussein Onn Malaysia
Suratun Nafisah Institut Teknologi Sumatera
Nur Liyana Razali Universiti Tun Hussein Onn Malaysia
Iwantono Universitas Riau

DOI:

https://doi.org/10.31436/iiumej.v25i1.2811

Keywords:

gold nanobipyramids, glucose, plasmonic sensor, thiol

Abstract

Gold nanobipyramids (GNBPs) have high selectivity in detecting changes in their surrounding medium because of their electric field enhancements and larger surface areas. In this study, we functionalized GNBPs using a thiol group that acts as a ligand to improve the detection performance of the analytes. The investigation is carried out by varying the functionalization periods from 12 to 72 hours. The optimum thiol-functionalized GNBPs (t-GNBPs) are obtained in 60 hours, with a length of 36.84 ± 2.05 nm, a width of 24.02 ± 0.74 nm, and an aspect ratio of 1.54 ± 0.11. Then, the optimum t-GNBPs are used as a sensing material in a plasmonic sensor to detect glucose. The limit of detection (LoD) of glucose is 1 µM for this sensor. The plasmonic sensor has been successfully built with reliable performance in detecting glucose with excellent linearity, sensitivity and R² = 1; good selectivity compared to four similar chemical structure analytes; high stability with a low error value, i.e., ± 0.02 a.u.; and almost consistent repeatability values in each cycle with low percent variance of 0.000025% for the t-SPR area and 0.000032% for the l-SPR area. Therefore, a plasmonic sensor based on t-GNBPs is an alternative method of detecting glucose with high sensitivity, selectivity and repeatability.

ABSTRAK: Nanobipiramid Emas (GNBPs) memiliki selektiviti yang tinggi dalam mengesan perubahan medium sekitar kerana memiliki peningkatan medan elektrik dan luas permukaan yang besar. Kajian ini merupakan fungsionalisasi terhadap GNBPs dengan menggunakan kumpulan thiol sebagai ligan bagi meningkatkan prestasi pengesanan analit. Kajian ini dilakukan dengan mempelbagaikan tempoh masa fungsionalisasi dalam julat waktu 12 hingga 72 jam. GNBPs optimum yang difungsionalisasi oleh thiol (t-GNBPs) diperoleh pada 60 jam, dengan panjang 36.84 ± 2.05 nm, lebar 24.02 ± 0.74 nm, dan nisbah aspek 1.54 ± 0.11. Kemudian, t-GNBPs optimum digunakan sebagai bahan penderia pada sensor plasmonik bagi mengesan glukosa. Limit pengesanan glukosa (LoD) bagi sensor ini adalah sebanyak 10⁰ µM. Sensor plasmonik telah berhasil dibangunkan dengan kecekapan boleh percaya dalam mengesan glukosa dengan lineariti dan sensitiviti sebanyak R² = 1. Pemilihan yang baik dibandingkan dengan 4 analit yang sama dari segi struktur kimia. Kestabilan yang tinggi dengan nilai ralat rendah iaitu ± 0.02 a.u, dan memiliki nilai keberulangan yang hampir konsisten pada setiap kitar dengan peratusan varian rendah iaitu sebanyak 0.000025% bagi bahagian t-SPR dan 0.000032% bagi l-SPR. Oleh itu, pengesan plasmonik berdasarkan t-GNBPs ini adalah kaedah alternatif bagi mengesan glukosa dengan sensitiviti, selektiviti, dan kebolehulangan yang tinggi.

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