Tools to evaluate the impact of nutrition delivery on muscle and physical-related outcomes in critical care: a scoping review
DOI:
https://doi.org/10.31436/ijohs.v6i1.356Keywords:
critical care, functional outcomes, nutrition therapy, scoping reviewAbstract
Understanding the impact of nutrition delivery on critically ill patient-centered outcomes is crucial. Patient-centered outcomes should be physical-related due to the natural course of catabolism experienced during critical illness. This review aims to map the existing tools used in research to evaluate the impact of nutrition delivery on muscle and physical-related outcomes among intensive care unit (ICU) patients. A search was conducted in PubMed and Scopus, initially yielding 502 articles published since 2010 on the topic using search terms related to ICU patients, muscle and physical outcomes, and nutrition delivery. Articles were screened based on inclusion criteria, resulting in 45 articles included in the analysis. Findings indicated that the outcome domains used ranged from muscle strength, muscle mass, to function. Imaging techniques and performance-based measures were the most used type of tools, with varying comprehensiveness, precision, simplicity, and feasibility. Despite most studies using repeated measurements throughout ICU stays, challenges in performing comprehensive assessments were reported. This review provides an overview of the assessment tools utilized in ICU nutritional research, highlighting the variability of choice that can be suited with researcher’s objectives and the availability of resources. To improve consistency and comparability across studies, future research should focus on developing standardized protocols for selecting appropriate tools to measure the effects of nutrition delivery on muscle and physical-related outcomes.
References
Arabi, Y. M., Al-Dorzi, H. M., Tamim, H., Sadat, M., Al-Hameed, F., AlGhamdi, A., et al. (2021). Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial). Clinical Nutrition ESPEN, 44, 166-172. https://doi.org/10.1016/j.clnesp.2021.05.008 DOI: https://doi.org/10.1016/j.clnesp.2021.05.008
Azevedo, J. R. A., Lima, H. C. M., Montenegro, W. S., Souza, S. C. C., Nogueira, I., Silva, M. M., et al. (2019). Optimized calorie and high protein intake versus recommended caloric-protein intake in critically ill patients: a prospective, randomized, controlled phase II clinical trial. Revista Brasileira de Terapia Intensiva, 31(2), 171-179. https://doi.org/10.5935/0103-507x.20190025 DOI: https://doi.org/10.5935/0103-507X.20190025
Badjatia, N., Sanchez, S., Judd, G., Hausladen, R., Hering, D., Motta, M., et al. (2021). Neuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial. Neurocritical Care, 35(1), 46-55. https://doi.org/10.1007/s12028-020-01138-4 DOI: https://doi.org/10.1007/s12028-020-01138-4
Barth, I., Beumeler, L. F. E., Nahar-van Venrooij, L., van Dijk, O., Buter, H., & Boerma, E. C. (2023). The effect of protein provision and exercise therapy on patient-reported and clinical outcomes in intensive care unit survivors: a systematic review. Journal of Human Nutrition and Dietetics, 36(5), 1727-1740. https://doi.org/10.1111/jhn.13188 DOI: https://doi.org/10.1111/jhn.13188
Bear, D. E., Griffith, D., & Puthucheary, Z. A. (2018). Emerging outcome measures for nutrition trials in the critically ill. Current Opinion in Clinical Nutrition & Metabolic Care, 21(6), 417-422. https://doi.org/10.1097/mco.0000000000000507 DOI: https://doi.org/10.1097/MCO.0000000000000507
Bear, D. E., Wandrag, L., Merriweather, J. L., Connolly, B., Hart, N., & Grocott, M. P. W. (2017). The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review. Critical Care, 21(1), 226. https://doi.org/10.1186/s13054-017-1810-2 DOI: https://doi.org/10.1186/s13054-017-1810-2
Bels, J. L. M., Ali Abdelhamid, Y., & van de Poll, M. C. G. (2023). Protein supplementation in critical illness: why, when and how? Current Opinion in Clinical Nutrition & Metabolic Care, 26(2), 146-153. https://doi.org/10.1097/mco.0000000000000912 DOI: https://doi.org/10.1097/MCO.0000000000000912
Berger, M. M., Pantet, O., Jacquelin-Ravel, N., Charrière, M., Schmidt, S., Becce, F., et al. (2019). Supplemental parenteral nutrition improves immunity with unchanged carbohydrate and protein metabolism in critically ill patients: the SPN2 randomized tracer study. Clinical Nutrition, 38(5), 2408-2416. https://doi.org/10.1016/j.clnu.2018.10.023 DOI: https://doi.org/10.1016/j.clnu.2018.10.023
Bragança, R. D., Ravetti, C. G., Barreto, L., Ataíde, T. B. L. S., Carneiro, R. M., Teixeira, A. L., et al. (2019). Use of handgrip dynamometry for diagnosis and prognosis assessment of intensive care unit acquired weakness: A prospective study. Heart & Lung, 48(6), 532-537. https://doi.org/https://doi.org/10.1016/j.hrtlng.2019.07.001 DOI: https://doi.org/10.1016/j.hrtlng.2019.07.001
Braunschweig, C. A., Sheean, P. M., Peterson, S. J., Gomez Perez, S., Freels, S., Troy, K. L., et al. (2014). Exploitation of diagnostic computed tomography scans to assess the impact of nutrition support on body composition changes in respiratory failure patients. Journal of Parenteral and Enteral Nutrition, 38(7), 880-885. https://doi.org/10.1177/0148607113500505 DOI: https://doi.org/10.1177/0148607113500505
Bury, C., DeChicco, R., Nowak, D., Lopez, R., He, L., Jacob, S., et al. (2021). Use of bedside ultrasound to assess muscle changes in the critically ill surgical patient. Journal of Parenteral and Enteral Nutrition, 45(2), 394-402. https://doi.org/https://doi.org/10.1002/jpen.1840 DOI: https://doi.org/10.1002/jpen.1840
Casaer, M. P., Langouche, L., Coudyzer, W., Vanbeckevoort, D., De Dobbelaer, B., Güiza, F. G., et al. (2013). Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness. Critical Care Medicine, 41(10), 2298-2309. https://doi.org/10.1097/CCM.0b013e31828cef02 DOI: https://doi.org/10.1097/CCM.0b013e31828cef02
Chapple, L. A., Gan, M., Louis, R., Yaxley, A., Murphy, A., & Yandell, R. (2020). Nutrition-related outcomes and dietary intake in non-mechanically ventilated critically ill adult patients: a pilot observational descriptive study. Australian Critical Care, 33(3), 300-308. https://doi.org/10.1016/j.aucc.2020.02.008 DOI: https://doi.org/10.1016/j.aucc.2020.02.008
Chapple, L. S., Summers, M. J., Weinel, L. M., & Deane, A. M. (2020). Outcome measures in critical care nutrition interventional trials: a systematic review. Nutrition in Clinical Practice, 35(3), 506-513. https://doi.org/10.1002/ncp.10478 DOI: https://doi.org/10.1002/ncp.10478
Chapple, L. S., Summers, M. J., Weinel, L. M., Lange, K., Yang, W. H., Deane, A. M., et al. (2022). Muscle size, strength, and physical function in response to augmented calorie delivery: A TARGET sub-study. Journal of Critical Care, 72, 154140. https://doi.org/10.1016/j.jcrc.2022.154140 DOI: https://doi.org/10.1016/j.jcrc.2022.154140
de Azevedo, J. R. A., Lima, H. C. M., Frota, P., Nogueira, I., de Souza, S. C., Fernandes, E. A. A., et al. (2021). High-protein intake and early exercise in adult intensive care patients: a prospective, randomized controlled trial to evaluate the impact on functional outcomes. BMC Anesthesiology, 21(1), 283. https://doi.org/10.1186/s12871-021-01492-6 DOI: https://doi.org/10.1186/s12871-021-01492-6
de Carvalho, D. A., Malaguti, C., Cabral, L. F., Oliveira, C. C., Annoni, R., & José, A. (2023). Upper limb function of individuals hospitalized in intensive care: A 6-month cohort study. Heart Lung, 57, 283-289. https://doi.org/10.1016/j.hrtlng.2022.10.011 DOI: https://doi.org/10.1016/j.hrtlng.2022.10.011
De Rosa, S., Umbrello, M., Pelosi, P., & Battaglini, D. (2023). Update on lean body mass diagnostic assessment in critical illness. Diagnostics, 13(5), 888. https://www.mdpi.com/2075-4418/13/5/888 DOI: https://doi.org/10.3390/diagnostics13050888
Deana, C., Gunst, J., De Rosa, S., Umbrello, M., Danielis, M., Biasucci, D. G., et al. (2024). Bioimpedance-assessed muscle wasting and its relation to nutritional intake during the first week of ICU: a pre-planned secondary analysis of Nutriti Study. Annals of Intensive Care, 14(1), 29. https://doi.org/10.1186/s13613-024-01262-w DOI: https://doi.org/10.1186/s13613-024-01262-w
Denehy, L., de Morton, N. A., Skinner, E. H., Edbrooke, L., Haines, K., Warrillow, S., et al. (2013). A physical function test for use in the intensive care unit: validity, responsiveness, and predictive utility of the physical function ICU test (Scored). Physical Therapy, 93(12), 1636-1645. https://doi.org/10.2522/ptj.20120310 DOI: https://doi.org/10.2522/ptj.20120310
Doig, G. S., Simpson, F., Sweetman, E. A., Finfer, S. R., Cooper, D. J., Heighes, P. T., et al. (2013). Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. Jama, 309(20), 2130-2138. https://doi.org/10.1001/jama.2013.5124 DOI: https://doi.org/10.1001/jama.2013.5124
Dresen, E., Siepmann, L., Weißbrich, C., Weinhold, L., Putensen, C., & Stehle, P. (2022). Is the amino acid pattern in medical nutrition therapy crucial for successfully attenuating muscle mass loss in adult ICU patients? Secondary analysis of a RCT. Clinical Nutrition ESPEN, 47, 36-44. https://doi.org/10.1016/j.clnesp.2021.12.021 DOI: https://doi.org/10.1016/j.clnesp.2021.12.021
Dresen, E., Weißbrich, C., Fimmers, R., Putensen, C., & Stehle, P. (2021). Medical high-protein nutrition therapy and loss of muscle mass in adult ICU patients: a randomized controlled trial. Clinical Nutrition, 40(4), 1562-1570. https://doi.org/10.1016/j.clnu.2021.02.021 DOI: https://doi.org/10.1016/j.clnu.2021.02.021
Dreydemy, G., Coussy, A., Lannou, A., Petit, L., Biais, M., & Carrié, C. (2021). Augmented renal clearance, muscle catabolism and urinary nitrogen loss: implications for nutritional support in critically ill trauma patients. Nutrients, 13(10). https://doi.org/10.3390/nu13103554 DOI: https://doi.org/10.3390/nu13103554
Elizabeth, N. S. H., Yanni, T., May, L. S., Fen, T. H., Janice, L. X., Peijun, K., et al. (2024). Indirect calorimetry directed feeding and cycling in the older ICU population: a pilot randomised controlled trial. BMC Anesthesiology, 24(1), 171. https://doi.org/10.1186/s12871-024-02507-8 DOI: https://doi.org/10.1186/s12871-024-02507-8
Fazzini, B., Märkl, T., Costas, C., Blobner, M., Schaller, S. J., Prowle, J., et al. (2023). The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Critical Care, 27(1), 2. https://doi.org/10.1186/s13054-022-04253-0 DOI: https://doi.org/10.1186/s13054-022-04253-0
Ferrie, S., Allman-Farinelli, M., Daley, M., & Smith, K. (2016). Protein requirements in the critically ill: a randomized controlled trial using parenteral nutrition. Journal of Parenteral and Enteral Nutrition, 40(6), 795-805. https://doi.org/10.1177/0148607115618449 DOI: https://doi.org/10.1177/0148607115618449
Fetterplace, K., Beach, L. J., MacIsaac, C., Presneill, J., Edbrooke, L., Parry, S. M., et al. (2019). Associations between nutritional energy delivery, bioimpedance spectroscopy and functional outcomes in survivors of critical illness. Journal of Human Nutrition and Dietetics, 32(6), 702-712. https://doi.org/10.1111/jhn.12659 DOI: https://doi.org/10.1111/jhn.12659
Fetterplace, K., Deane, A. M., Tierney, A., Beach, L. J., Knight, L. D., Presneill, J., et al. (2018). Targeted full energy and protein delivery in critically ill patients: a pilot randomized controlled trial (FEED trial). Journal of Parenteral and Enteral Nutrition, 42(8), 1252-1262. https://doi.org/10.1002/jpen.1166 DOI: https://doi.org/10.1002/jpen.1166
Hermans, G., Casaer, M. P., Clerckx, B., Güiza, F., Vanhullebusch, T., et al. (2013). Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. The Lancet Respiratory Medicine, 1(8), 621-629. https://doi.org/10.1016/s2213-2600(13)70183-8 DOI: https://doi.org/10.1016/S2213-2600(13)70183-8
Hill, A., Elke, G., & Weimann, A. (2021). Nutrition in the Intensive Care Unit-a narrative review. Nutrients, 13(8). https://doi.org/10.3390/nu13082851 DOI: https://doi.org/10.3390/nu13082851
Hofhuis, J. G., van Stel, H. F., Schrijvers, A. J., Rommes, J. H., & Spronk, P. E. (2015). ICU survivors show no decline in health-related quality of life after 5 years. Intensive Care Medicine, 41(3), 495-504. https://doi.org/10.1007/s00134-015-3669-5 DOI: https://doi.org/10.1007/s00134-015-3669-5
Hsu, C. C., Sun, C. Y., Tsai, C. Y., Chen, M. Y., Wang, S. Y., Hsu, J. T., et al. (2021). Metabolism of proteins and amino acids in critical illness: from physiological alterations to relevant clinical practice. Journal of Multidisciplinary Healthcare, 14, 1107-1117. https://doi.org/10.2147/jmdh.S306350 DOI: https://doi.org/10.2147/JMDH.S306350
Jubina, L. E., Locke, A., Fedder, K. R., Slone, S. A., Soper, M. K., Kalema, A. G., et al. (2023). Nutrition in the intensive care unit and early recovery influence functional outcomes for survivors of critical illness: A prospective cohort study. Journal of Parenteral and Enteral Nutrition, 47(7), 888-895. https://doi.org/10.1002/jpen.2538 DOI: https://doi.org/10.1002/jpen.2538
Kangalgil, M., Küçük, A. O., Ulusoy, H., & Özçelik, A. (2024). Nutrition determinants of acute skeletal muscle loss in critically ill patients: A prospective observational cohort study. Nutrition in Clinical Practice, 39(3), 579-588. https://doi.org/10.1002/ncp.11086 DOI: https://doi.org/10.1002/ncp.11086
Kim, H., & Choi-Kwon, S. (2011). Changes in nutritional status in ICU patients receiving enteral tube feeding: A prospective descriptive study. Intensive and Critical Care Nursing, 27(4), 194-201. https://doi.org/https://doi.org/10.1016/j.iccn.2011.05.002 DOI: https://doi.org/10.1016/j.iccn.2011.05.002
Lakenman, P. L. M., van Marwijk, I., van der Hoven, B., van Bommel, J., Joosten, K. F. M., & Olieman, J. F. (2024). Association between fat-free mass and survival in critically ill patients with COVID-19: a prospective cohort study. Journal of Parenteral and Enteral Nutrition, 48(2), 192-198. https://doi.org/10.1002/jpen.2585 DOI: https://doi.org/10.1002/jpen.2585
Lambell, K. J., Goh, G. S., Tierney, A. C., Forsyth, A., Nanjayya, V., Nyulasi, I., et al (2021). Marked losses of computed tomography–derived skeletal muscle area and density over the first month of a critical illness are not associated with energy and protein delivery. Nutrition, 82, 111061. https://doi.org/https://doi.org/10.1016/j.nut.2020.111061 DOI: https://doi.org/10.1016/j.nut.2020.111061
Latronico, N., Herridge, M., Hopkins, R. O., Angus, D., Hart, N., Hermans, et al. (2017). The ICM research agenda on intensive care unit-acquired weakness. Intensive Care Medicine, 43(9), 1270-1281. https://doi.org/10.1007/s00134-017-4757-5 DOI: https://doi.org/10.1007/s00134-017-4757-5
Liu, Y., Zhao, W., Chen, W., Shen, X., Fu, R., Zhao, Y., et al. (2020). Effects of early enteral nutrition on immune function and prognosis of patients with sepsis on mechanical ventilation. Journal of Intensive Care Medicine, 35(10), 1053-1061. https://doi.org/10.1177/0885066618809893 DOI: https://doi.org/10.1177/0885066618809893
Matsushima, S., Yoshida, M., Yokoyama, H., Watanabe, Y., Onodera, H., Wakatake, H., et al. (2021). Effects on physical performance of high protein intake for critically ill adult patients admitted to the intensive care unit: a retrospective propensity-matched analysis. Nutrition, 91-92, 111407. https://doi.org/10.1016/j.nut.2021.111407 DOI: https://doi.org/10.1016/j.nut.2021.111407
McNelly, A. S., Bear, D. E., Connolly, B. A., Arbane, G., Allum, L., Tarbhai, A., et al. (2020). Effect of intermittent or continuous feed on muscle wasting in critical illness: a phase 2 clinical trial. Chest, 158(1), 183-194. https://doi.org/10.1016/j.chest.2020.03.045 DOI: https://doi.org/10.1016/j.chest.2020.03.045
Mourtzakis, M., Parry, S., Connolly, B., & Puthucheary, Z. (2017). Skeletal muscle ultrasound in critical care: a tool in need of translation. Annals of the American Thoracic Society, 14(10), 1495-1503. https://doi.org/10.1513/AnnalsATS.201612-967PS DOI: https://doi.org/10.1513/AnnalsATS.201612-967PS
Nakamura, K., Kihata, A., Naraba, H., Kanda, N., Takahashi, Y., Sonoo, T., et al. (2020). ?-Hydroxy-?-methylbutyrate, arginine, and glutamine complex on muscle volume loss in critically ill patients: a randomized control trial. Journal of Parenteral and Enteral Nutrition, 44(2), 205-212. https://doi.org/10.1002/jpen.1607 DOI: https://doi.org/10.1002/jpen.1607
Nakamura, K., Nakano, H., Naraba, H., Mochizuki, M., Takahashi, Y., Sonoo, T., et al. (2021). High protein versus medium protein delivery under equal total energy delivery in critical care: A randomized controlled trial. Clinical Nutrition, 40(3), 796-803. https://doi.org/10.1016/j.clnu.2020.07.036 DOI: https://doi.org/10.1016/j.clnu.2020.07.036
Nakano, H., Naraba, H., Hashimoto, H., Mochizuki, M., Takahashi, Y., Sonoo, T., et al. (2021). Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle. Critical Care, 25(1), 415. https://doi.org/10.1186/s13054-021-03827-8 DOI: https://doi.org/10.1186/s13054-021-03827-8
Nickels, M. R., Blythe, R., White, N., Ali, A., Aitken, L. M., Heyland, D. K., et al. (2023). Predictors of acute muscle loss in the intensive care unit: a secondary analysis of an in-bed cycling trial for critically ill patients. Australian Critical Care, 36(6), 940-947. https://doi.org/10.1016/j.aucc.2022.12.015 DOI: https://doi.org/10.1016/j.aucc.2022.12.015
Nordon-Craft, A., Schenkman, M., Edbrooke, L., Malone, D. J., Moss, M., & Denehy, L. (2014). The physical function intensive care test: implementation in survivors of critical illness. Physical Therapy, 94(10), 1499-1507. https://doi.org/10.2522/ptj.20130451 DOI: https://doi.org/10.2522/ptj.20130451
Özyürek, S., Saraç, D. C., Savc?, S., Koca, U., Cömert, B., & Gökmen, N. (2017). Is handgrip strength a simple surrogate determiner for global, upper, and lower limb strength in critically ill patients? European Respiratory Journal, 50(suppl 61), PA2555. https://doi.org/10.1183/1393003.congress-2017.PA2555 DOI: https://doi.org/10.1183/1393003.congress-2017.PA2555
Pardo, E., El Behi, H., Boizeau, P., Verdonk, F., Alberti, C., & Lescot, T. (2018). Reliability of ultrasound measurements of quadriceps muscle thickness in critically ill patients. BMC Anesthesiology, 18(1), Article 205. https://doi.org/10.1186/s12871-018-0647-9 DOI: https://doi.org/10.1186/s12871-018-0647-9
Parry, S. M., Huang, M., & Needham, D. M. (2017). Evaluating physical functioning in critical care: considerations for clinical practice and research. Critical Care, 21(1), 249. https://doi.org/10.1186/s13054-017-1827-6 DOI: https://doi.org/10.1186/s13054-017-1827-6
Preiser, J.-C., Ichai, C., & Groeneveld, A. B. J. (2016). Successive Phases of the Metabolic Response to Stress. In J.-C. Preiser (Ed.), The Stress Response of Critical Illness: Metabolic and Hormonal Aspects (pp. 5-18). Springer International Publishing. https://doi.org/10.1007/978-3-319-27687-8_2 DOI: https://doi.org/10.1007/978-3-319-27687-8_2
Preiser, J. C., Ichai, C., Orban, J. C., & Groeneveld, A. B. (2014). Metabolic response to the stress of critical illness. British Journal of Anaesthesia, 113(6), 945-954. https://doi.org/10.1093/bja/aeu187 DOI: https://doi.org/10.1093/bja/aeu187
Ridley, E. J., Davies, A. R., Parke, R., Bailey, M., McArthur, C., Gillanders, L., et al. (2018). Supplemental parenteral nutrition versus usual care in critically ill adults: a pilot randomized controlled study. Critical Care, 22(1), 12. https://doi.org/10.1186/s13054-018-1939-7 DOI: https://doi.org/10.1186/s13054-018-1939-7
Rooyackers, O., & Wernerman, J. (2014). Imaging opens possibilities both to target and to evaluate nutrition in critical illness. Critical Care, 18(3), 144. https://doi.org/10.1186/cc13882 DOI: https://doi.org/10.1186/cc13882
Singer, P., Blaser, A. R., Berger, M. M., Calder, P. C., Casaer, M., Hiesmayr, M., et al. (2023). ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit. Clinical Nutrition, 42(9), 1671-1689. https://doi.org/10.1016/j.clnu.2023.07.011 DOI: https://doi.org/10.1016/j.clnu.2023.07.011
Sundström-Rehal, M., Tatucu-Babet, O. A., & Oosterveld, T. (2023). Indirect calorimetry: should it be part of routine care or only used in specific situations? Current Opinion in Clinical Nutrition & Metabolic Care, 26(2), 154-159. https://doi.org/10.1097/mco.0000000000000895 DOI: https://doi.org/10.1097/MCO.0000000000000895
Taverny, G., Lescot, T., Pardo, E., Thonon, F., Maarouf, M., & Alberti, C. (2019). Outcomes used in randomised controlled trials of nutrition in the critically ill: a systematic review. Critical Care, 23(1), 12. https://doi.org/10.1186/s13054-018-2303-7 DOI: https://doi.org/10.1186/s13054-018-2303-7
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., et al. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Annals of Internal Medicine, 169(7), 467-473. https://doi.org/10.7326/m18-0850 DOI: https://doi.org/10.7326/M18-0850
Umbrello, M., Brogi, E., Formenti, P., Corradi, F., & Forfori, F. (2023). ultrasonographic features of muscular weakness and muscle wasting in critically ill patients. Journal of Clinical Medicine, 13(1). https://doi.org/10.3390/jcm13010026 DOI: https://doi.org/10.3390/jcm13010026
Umbrello, M., Guglielmetti, L., Formenti, P., Antonucci, E., Cereghini, S., Filardo, C., et al. (2021). Qualitative and quantitative muscle ultrasound changes in patients with COVID-19-related ARDS. Nutrition, 91-92, 111449. https://doi.org/10.1016/j.nut.2021.111449 DOI: https://doi.org/10.1016/j.nut.2021.111449
Uyar, E., Yagmurdur, H., Yamanyar, S., Güdek, Y., Dal, M. C., & Cosar, A. (2023). The effect of protein enriched nutrition on diaphragm function in mechanically ventilated patients. Nutrition Clinique et Métabolisme, 37(1), 31-38. https://doi.org/https://doi.org/10.1016/j.nupar.2022.10.001 DOI: https://doi.org/10.1016/j.nupar.2022.10.001
Van Zanten, A. R. H., De Waele, E., & Wischmeyer, P. E. (2019). Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases. Critical Care, 23(1), 368. https://doi.org/10.1186/s13054-019-2657-5 DOI: https://doi.org/10.1186/s13054-019-2657-5
Verceles, A. C., Serra, M., Davis, D., Alon, G., Wells, C. L., Parker, E., et al. (2023). Combining exercise, protein supplementation and electric stimulation to mitigate muscle wasting and improve outcomes for survivors of critical illness-The ExPrES study. Heart Lung, 58, 229-235. https://doi.org/10.1016/j.hrtlng.2022.11.013 DOI: https://doi.org/10.1016/j.hrtlng.2022.11.013
Viana, M. V., Becce, F., Pantet, O., Schmidt, S., Bagnoud, G., Thaden, J. J., et al. (2021). Impact of ?-hydroxy-?-methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT. Clinical Nutrition, 40(8), 4878-4887. https://doi.org/10.1016/j.clnu.2021.07.018 DOI: https://doi.org/10.1016/j.clnu.2021.07.018
Wang, Y., Ye, Y., Xuan, L., Xu, L., Wang, P., Ma, J., et al. (2024). Impact of early high protein intake in critically ill patients: a randomized controlled trial. Nutrition Metabolism (Lond), 21(1), 39. https://doi.org/10.1186/s12986-024-00818-8 DOI: https://doi.org/10.1186/s12986-024-00818-8
Wischmeyer, P. E. (2016). Are we creating survivors…or victims in critical care? Delivering targeted nutrition to improve outcomes. Curr Opin Critical Care, 22(4), 279-284. https://doi.org/10.1097/mcc.0000000000000332 DOI: https://doi.org/10.1097/MCC.0000000000000332
Wischmeyer, P. E., Bear, D. E., Berger, M. M., De Waele, E., Gunst, J., McClave, S. A., et al. (2023). Personalized nutrition therapy in critical care: 10 expert recommendations. Critical Care, 27(1), 261. https://doi.org/10.1186/s13054-023-04539-x DOI: https://doi.org/10.1186/s13054-023-04539-x
Wischmeyer, P. E., Hasselmann, M., Kummerlen, C., Kozar, R., Kutsogiannis, D. J., Karvellas, C. J., et al. (2017). A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Critical Care, 21(1), 142. https://doi.org/10.1186/s13054-017-1736-8 DOI: https://doi.org/10.1186/s13054-017-1736-8
Wittholz, K., Fetterplace, K., Clode, M., George, E. S., MacIsaac, C. M., Judson, R., et al. (2020). Measuring nutrition-related outcomes in a cohort of multi-trauma patients following intensive care unit discharge. Journal of Human Nutrition and Dietetics, 33(3), 414-422. https://doi.org/10.1111/jhn.12719 DOI: https://doi.org/10.1111/jhn.12719
Wittholz, K., Fetterplace, K., Karahalios, A., Ali Abdelhamid, Y., Beach, L., Read, D., et al. (2023). Beta-hydroxy-beta-methylbutyrate supplementation and functional outcomes in multitrauma patients: a pilot randomized controlled trial. Journal of Parenteral and Enteral Nutrition, 47(8), 983-992. https://doi.org/10.1002/jpen.2527 DOI: https://doi.org/10.1002/jpen.2527
Yatabe, T., Egi, M., Sakaguchi, M., Ito, T., Inagaki, N., Kato, H., et al. (2019). Influence of nutritional management and rehabilitation on physical outcome in japanese intensive care unit patients: a multicenter observational study. Annals of Nutrition and Metabolism, 74(1), 35-43. https://doi.org/10.1159/000495213 DOI: https://doi.org/10.1159/000495213
Yeh, D. D., Ortiz-Reyes, L. A., Quraishi, S. A., Chokengarmwong, N., Avery, L., Kaafarani, H. M. A., et al. (2018). Early nutritional inadequacy is associated with psoas muscle deterioration and worse clinical outcomes in critically ill surgical patients. Journal of Critical Care, 45, 7-13. https://doi.org/10.1016/j.jcrc.2017.12.027 DOI: https://doi.org/10.1016/j.jcrc.2017.12.027
Youssef, I. A., Hasan, K. N., & Mohmed, A. H. (2022). Effects of parenteral protein concentrations in critically ill patients in icu: a comparative study. Bali Journal of Anesthesiology, 6(2), 85-90. https://doi.org/10.4103/bjoa.bjoa_57_22 DOI: https://doi.org/10.4103/bjoa.bjoa_57_22
Zaragoza-García, I., Arias-Rivera, S., Frade-Mera, M. J., Martí, J. D., Gallart, E., San José-Arribas, A., et al. (2023). Enteral nutrition management in critically ill adult patients and its relationship with intensive care unit-acquired muscle weakness: a national cohort study. PLOS ONE, 18(6), e0286598. https://doi.org/10.1371/journal.pone.0286598 DOI: https://doi.org/10.1371/journal.pone.0286598
Zhang, Q., Wang, X., Liu, M., Li, B., Zhang, K., Han, Y., et al. (2024). Assessing the diagnostic efficacy of handgrip dynamometry and diaphragmatic ultrasound in intensive care unit-acquired weakness. Journal of Multidisciplinary Healthcare, 17, 2359-2370. https://doi.org/10.2147/jmdh.S462297 DOI: https://doi.org/10.2147/JMDH.S462297
Zhang, Q., Zhou, J., Zhu, D., & Zhou, S. (2022). Evaluation of the effect of high protein supply on diaphragm atrophy in critically ill patients receiving prolonged mechanical ventilation. Nutrition in Clinical Practice, 37(2), 402-412. https://doi.org/10.1002/ncp.10672 DOI: https://doi.org/10.1002/ncp.10672