THE THERAPEUTIC POTENTIAL OF NIGELLA SATIVA IN THE INHIBITION OF ADVANCED GLYCATION END PRODUCT (AGE) FORMATION: A SYSTEMATIC REVIEW
Introduction: The purpose of this paper is to systematically review the therapeutic potential of Nigella sativa in the inhibition of AGE formation and its properties that regulate AGE level. Methods: The selected studies consist of interventions towards in vitro samples from blood origin and compared AGE inhibition between treated and untreated control groups. Six databases were searched for related articles using keywords derived using PICO format. Six articles were accepted as meeting the inclusion criterion and were reviewed for the effectiveness of Nigella sativa in AGE inhibition. Results: All studies showed positive results. These studies demonstrated significant and dose dependent activity of Nigella sativa in inhibiting AGE formation, presenting significant results even at lower concentrations. Thymoquinone was consistently identified as the component associated with the antiglycating effect of Nigella sativa. Conclusion: This review provides evidence for the decreased formation of AGEs in the presence of Nigella sativa proposing its use as a natural antiglycating drug and its effectiveness in the treatment of diabetes, its complications and other AGE-related diseases.