Single nucleotide polymorphism of leptin and leptin receptor genes in oral cancer - A systematic review

Siti Hana Ilyana  Hasanbasri; Nur Armidha Nadihah  Amir Sabri; Khairani Idah Mokhtar; Basma  Ezzat Mustafa; Mohamad Shafiq  Mohd Ibrahim; Pram Kumar   Subramaniam

doi:10.31436/ijohs.v5i2.283

Authors

Siti Hana Ilyana Hasanbasri Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Nur Armidha Nadihah Amir Sabri Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Khairani Idah Mokhtar Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Basma Ezzat Mustafa Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Mohamad Shafiq Mohd Ibrahim Department of Paediatric Dentistry and Dental Public Health, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Pram Kumar Subramaniam Department of Oral Maxillofacial Surgery and Oral Diagnosis, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia & Oral Dental and Maxillofacial Surgery Unit, Sultan Ahmad Shah Medical Centre, International Islamic University Malaysia, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.

DOI:

https://doi.org/10.31436/ijohs.v5i2.283

Keywords:

leptin, leptin receptor, oral cancer, oral squamous cell carcinoma, single nucleotide polymorphism

Abstract

Oral cancer is one of the serious health problems diagnosed worldwide including Malaysia. While much research has been done on the gene polymorphism of leptin and leptin receptor genes in other cancers, few researchers have considered oral cancer. Hence, this study aims to provide an insight into the association of a single nucleotide polymorphism of leptin and leptin receptor genes with oral cancer, as well as its contribution in increasing the risk for oral cancer development. Literature searches were conducted in six databases including Scopus, ScienceDirect, Web of Science, PubMed, Google Scholar, and Dimensions; focusing on articles published between 2000 to 2020. All relevant articles were screened accordingly using search terms “leptin”, “leptin receptor”, “single nucleotide polymorphism” and “oral cancer”. A total of 2699 articles were retrieved. After following the inclusion and exclusion criteria, only four articles were included in this systematic review highlighting the three commonly studied polymorphic variant of leptin and leptin receptor which are LEP -2548 G/A, LEPR Gln223Arg, and LEPR K109R. Single nucleotide polymorphism of leptin and leptin receptor genes specifically LEPR Gln223Arg and LEP -2548 G/A may increase the risk of development of oral cancer. There were limited sources available to support the findings. Further research and investigations are needed to explore the mechanism of leptin and leptin receptor genes in the development of oral cancer.

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