Genetics of malocclusion: A review

Khairani Idah  Mokhtar; Noraini Abu Bakar; Aisyah Hanani  Md Ali Tahir

doi:10.31436/ijohs.v1i1.2

Authors

Khairani Idah Mokhtar Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, IIUM Kuantan Campus.
Noraini Abu Bakar Department of Orthodontics, Kulliyyah of Dentistry, IIUM Kuantan Campus.
Aisyah Hanani Bt Md Ali Tahir Department of Biomedical Science, Kulliyyah of Allied Health Sciences, IIUM Kuantan Campus. Abstract

DOI:

https://doi.org/10.31436/ijohs.v1i1.2

Keywords:

malocclusion, genes

Abstract

Malocclusion is one of the most common craniofacial problems observed worldwide. Affected individuals suffer not only from aesthetic concerns but also from functional problems, such as with mastication and pronunciation. The prevalence of malocclusion in East Asians is higher than in other races. Reports have shown besides environmental factors, there is association between certain types of malocclusion with specific genes. Positive association of mandibular prognathism has been implicated to genes such as Matrilin-1; while mutation in DUSP6 has also been shown to contribute to the incidence of malocclusion. This review aimed to briefly discuss the involvement of other additional genes such as MYO1H and PAX9 in the incidence of malocclusion as observed from our local institution.

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