Intestinal Barrier Integrity: The Essential Role of  Neuropeptides and Their Implications in the  Pathogenesis of Gastrointestinal Diseases:

Lyana Syazana Mat Nawi; Yeong Yeh  Lee; Siti Norasikin Mohd Nafi; Anani Aila Mat Zin; Wan Sarah Zainina  Wan Mohd Zahiruddin; Suk Peng Tang

doi:10.31436/imjm.v24i02.2712

Intestinal Barrier Integrity: The Essential Role of Neuropeptides and Their Implications in the Pathogenesis of Gastrointestinal Diseases

Authors

Lyana Syazana Mat Nawi Universiti Sains Malaysia
Yeong Yeh Lee Universiti Sains Malaysia
Siti Norasikin Mohd Nafi Universiti Sains Malaysia
Anani Aila Mat Zin Universiti Sains Malaysia
Wan Sarah Zainina Wan Mohd Zahiruddin Universiti Sains Malaysia
Suk Peng Tang Universiti Sains Malaysia

DOI:

https://doi.org/10.31436/imjm.v24i02.2712

Keywords:

intestinal barrier, neuropeptide Y, vasoactive intestinal peptide, cholecystokinin, substance P

Abstract

The intestinal barrier relies on tight junctions and proteins including claudins, occludins, and zonula occludens, helping to seal the epithelial cell gaps and hence controlling permeability. When tight junctions are disrupted, intestinal permeability increases, a condition recognised as "leaky gut." This condition is linked to gastrointestinal (GI) disorders including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Neuropeptides are crucial in modulating the tight junctions’ integrity within the GI epithelial barrier. This review focuses on neuropeptide Y, vasoactive intestinal peptide, cholecystokinin, and substance P in regulating intestinal barrier integrity. Studies included in this narrative review were selected based on their relevance to the topic, identified through searches in databases such as Google Scholar, PubMed, and Mendeley using relevant keywords. Understanding the mechanisms of these neuropeptides may provide pathophysiological insights and potential treatment strategies for restoring intestinal barrier integrity in GI disorders.

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Published

01.04.2025

How to Cite

Mat Nawi, L. S., Lee, Y. Y., Mohd Nafi, S. N., Mat Zin, A. A., Wan Mohd Zahiruddin, W. S. Z., & Tang, S. P. (2025). Intestinal Barrier Integrity: The Essential Role of Neuropeptides and Their Implications in the Pathogenesis of Gastrointestinal Diseases: . IIUM Medical Journal Malaysia, 24(02). https://doi.org/10.31436/imjm.v24i02.2712

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Issue

Vol. 24 No. 02 (2025): IUM Medical Journal Malaysia - April 2025

Section

Review Article

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