Effects of Time Delay in Processing Common Clinical Biochemical Parameters in an Accredited Laboratory

Julia Omar; Wan Norlina Wan Azman; Tan Say Koon; Nor Aziantie  Abdul Wahab; Samantha Xin-Yuin; Law Xi Ling; Chew Hsiao Junn; Azlan  Husin; Hans Van Rostenberghe; Mohamed Rusli  Abdullah

doi:10.31436/imjm.v21i4.2070

Effects of Time Delay in Processing Common Clinical Biochemical Parameters in an Accredited Laboratory

Authors

Julia Omar School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Wan Norlina Wan Azman School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Tan Say Koon School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Nor Aziantie Abdul Wahab School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Samantha Xin-Yuin Hospital Taiping, Jalan Taming Sari,Taiping, Perak, Malaysia.
Law Xi Ling School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Chew Hsiao Junn School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Azlan Husin 1School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Hans Van Rostenberghe School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Mohamed Rusli Abdullah School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

DOI:

https://doi.org/10.31436/imjm.v21i4.2070

Keywords:

stability of laboratory test, time delay, processing, serum, biochemistry analytes

Abstract

INTRODUCTION: Analyte stability time is challenging to employ in clinical settings. The diversity of processing time may affect the accuracy of results. This study evaluates the maximum time delay permissible before sample centrifugation and analysis. MATERIALS AND METHODS: We evaluated 15 serum electrolytes in 40 samples centrifuged and analysed using an automated analyser. The time was divided into 1, 2, 6, and 24 hours. RESULTS: Most analytes studied remained stable for up to 24 hours before centrifugation. However, delayed processing affected the value of potassium, magnesium, LDH, and calcium after 2 hours up to a maximum of 6 hours at room temperature for total protein, phosphate, and sodium. CONCLUSIONS: Most analytes were unaffected by a delay in centrifugation at room temperatures, but several critical analytes were severely affected.

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Published

01.10.2022

How to Cite

Julia Omar, Wan Azman, W. N., Tan Say Koon, Abdul Wahab, N. A. ., Samantha Xin-Yuin, Law Xi Ling, Chew Hsiao Junn, Husin, A. ., Hans Van Rostenberghe, & Abdullah, M. R. . (2022). Effects of Time Delay in Processing Common Clinical Biochemical Parameters in an Accredited Laboratory. IIUM Medical Journal Malaysia, 21(4). https://doi.org/10.31436/imjm.v21i4.2070

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Issue

Vol. 21 No. 4 (2022): IIUM Medical Journal Malaysia - October 2022

Section

Original Articles

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