Oral Doxycycline on the Level of Matrix Metalloproteinase 9 in Rat Models Experiencing Traumatic Brain Injury

Authors

  • Faruk M
  • Daud K.R.
  • Islam A.A.
  • Ihwan A.
  • Alfian Zainuddin A.A

DOI:

https://doi.org/10.31436/imjm.v20i1.1773

Abstract

 

INTRODUCTION: Cerebral edema in traumatic brain injury (TBI) results from hyperpermeability of the bloodbrain barrier (BBB). One of the causes in BBB permeability disorders is the activation of matrix metalloproteinase 9 (MMP-9) which can be inhibited by the administration of doxycycline. Knowing the role of oral doxycycline administration as an inhibitor of MMP-9 activation on the level of MMP-9 in cerebral edema in traumatic brain injury. MATERIALS AND METHODS: This study was an experimental study in Wistar rats with a post-test control design consisting of one control group, one group with provoked brain injury, and one group with provoked brain injury followed by oral doxycycline administration. RESULT: There were significant differences in the level of MMP -9 between the control group, the provoked brain injury group and the provoked brain injury group followed by oral doxycycline administration with p-value = 0.01 (p<0.05). CONCLUSION: Oral doxycycline administration can inhibit the increase of MMP-9 levels in cerebral edema in traumatic brain injury in Wistar rats.

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Published

01.01.2021

How to Cite

M, F. ., K.R., D. ., A.A., I. ., A., . I. ., & A.A, . A. Z. . (2021). Oral Doxycycline on the Level of Matrix Metalloproteinase 9 in Rat Models Experiencing Traumatic Brain Injury . IIUM Medical Journal Malaysia, 20(1). https://doi.org/10.31436/imjm.v20i1.1773