Correlation of E-cadherin Expression in Endometrial Carcinoma with Tumour Grade and Stage

Authors

  • Lizawati RH Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre
  • Nur Maya Sabrina TL Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre
  • Muhammad Fakhri MS Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre
  • Nordashima AS Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre
  • Azmawati MN Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre

DOI:

https://doi.org/10.31436/imjm.v20i3.1737

Keywords:

endometrial carcinoma, E-cadherin, tumour, gynaecology, pathology

Abstract

INTRODUCTION: Endometrial carcinoma (EC) is among the common malignancy in the female with adverse prognosis in the advanced stage. Prediction of its prognosis is important in stratifying EC patients to achieve optimum treatment and improve clinical outcomes. This study is aimed to evaluate the prognostic significance of E-cadherin expression in patients with EC. The present study also investigated the correlation of E-cadherin expression in EC with its tumour grade and stage. MATERIALS AND METHODS: A total of 70 cases of EC were included in the study within eleven years comprising 56 cases of endometrioid carcinoma, 2 cases of mucinous carcinoma, 10 cases of serous carcinoma and 2 cases of clear cell carcinoma. E-cadherin expression was immunohistochemically analysed and compared with clinicopathological parameters. RESULTS: E-cadherin loss of expression shows significant association with non endometrioid EC (p=0.003), high tumour grade (p<0.001) and tumour with distant metastasis (p=0.028). Tumour grade is the main predictor of down-regulation of E-cadherin expression (Grade 3: aOR 8.400, 95%CI 2.534-27.842). There was no significant association found between E-cadherin expression with myometrial invasion, FIGO stage, lymph node status and lymphovascular invasion. CONCLUSION: E-cadherin loss of expression correlates with poor prognostic factors namely high grade and high stage (metastasis) EC. This may serve as a potential prognostic marker for EC>< 0.001) and tumour with distant metastasis (p=0.028). Tumour grade is the main predictor of down-regulation of E-cadherin expression (Grade 3: aOR 8.400, 95%CI 2.534-27.842). There was no significant association found between E-cadherin expression with myometrial invasion, FIGO stage, lymph node status and lymphovascular invasion.

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Published

01.07.2021

How to Cite

RH, L., Sabrina TL, N. M. ., MS, M. F. ., AS, N. ., & MN, A. . (2021). Correlation of E-cadherin Expression in Endometrial Carcinoma with Tumour Grade and Stage. IIUM Medical Journal Malaysia, 20(3). https://doi.org/10.31436/imjm.v20i3.1737