Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

Che Nor Zarida  Che Seman; Zamzuri  Zakaria; Zunariah  Buyong; Mohd Shukrimi  Awang; Ahmad Razali Md Ralib @  Md Raghib

doi:10.31436/imjm.v16i1.1169

Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

Authors

Che Nor Zarida Che Seman
Zamzuri Zakaria
Zunariah Buyong
Mohd Shukrimi Awang
Ahmad Razali Md Ralib @ Md Raghib

DOI:

https://doi.org/10.31436/imjm.v16i1.1169

Abstract

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

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Published

01.06.2017

How to Cite

Che Seman, C. N. Z. ., Zakaria, . Z. ., Buyong, Z. ., Awang, . M. S. ., & Md Raghib, A. R. M. R. @ . (2017). Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste). IIUM Medical Journal Malaysia, 16(1). https://doi.org/10.31436/imjm.v16i1.1169

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Issue

Vol. 16 No. 1 (2017): Volume 16 Supplementary Issue No 1

Section

Supplementary Abstract

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