SYSTEMATIC REVIEW ON ROLE OF miRNAs IN ACUTE MYOCARDIAL INFARCTION OF YOUNG ADULTS

Authors

  • Nurul Ashikin Muhammad Musa International Islamic University Malaysia, Malaysia
  • Nor Zamzila Abdullah International Islamic University Malaysia, Malaysia
  • Norlelawati A. Talib International Islamic University Malaysia, Malaysia
  • Azliana Abd Fuaat International Islamic University Malaysia, Malaysia
  • Aszrin Abdullah International Islamic University Malaysia, Malaysia

DOI:

https://doi.org/10.31436/ijahs.v5i1.603

Abstract

Acute myocardial infarction (AMI) is the leading cause of death worldwide. In Malaysia, people are getting AMI at younger age compared to well-developed countries.  The role of microRNA (miRNA) in pathogenesis of AMI is not well elucidated and its involvement in young population has not been studied.  The systematic review performed using available electronic databases and also previous reviews.  The databases were broad search and began with the generic terms to identify search terms that were relevant.  Databases including PubMed, Science Direct and Medline were searched between January 2010 and December 2020 for this systematic review.  A total of 97 articles found. Only 1 article showed that the research was done in young AMI population.  13 miRNAs were found to be upregulated and 16 downregulated in young acute coronary syndrome (ACS) patient, which included both ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI).  miRNA 183-5p was significantly upregulated in ACS patients with NSTEMI whereas miRNA 134-5p, miRNA 15a-5p and let 7i-5p were significantly downregulated in patients with STEMI compared to healthy control.  Plasma miRNA 183-5p, miRNA 134-5p, miRNA 15a-5p and let 7i-5p were dysregulated in STEMI and NSTEMI where they can potentially be used to discriminate the two ACS forms in future study.

Downloads

Download data is not yet available.

Downloads

Published

2021-04-08

How to Cite

Muhammad Musa, N. A. ., Abdullah, N. Z. ., A. Talib, N. ., Abd Fuaat, A. ., & Abdullah, A. . (2021). SYSTEMATIC REVIEW ON ROLE OF miRNAs IN ACUTE MYOCARDIAL INFARCTION OF YOUNG ADULTS . INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES, 5(1), 2166. https://doi.org/10.31436/ijahs.v5i1.603

Most read articles by the same author(s)