MICRORNA AS A POTENTIAL BIOMARKER IN THE DIAGNOSIS AND PROGNOSIS OF HODGKIN’S LYMPHOMA: A SYSTEMATIC REVIEW

Authors

  • NIK NURDIYANA NIK IZHAR Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Haji Ahmad Shah, 25200 Kuantan, Pahang
  • MARDHIAH MOHAMMAD Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Haji Ahmad Shah, 25200 Kuantan, Pahang
  • ROZLIN ABDUL RAHMAN Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Haji Ahmad Shah, 25200 Kuantan, Pahang
  • NORAFIZA ZAINUDDIN International Islamic University Malaysia http://orcid.org/0000-0002-7481-8062

Abstract

Diagnosing Hodgkin’s Lymphoma (HL) has become a challenge nowadays and mostly limited to the current therapy. Thus, microRNA is believed to exhibit the best candidate for HL diagnosis and prognosis. To assess the true value of miRNA as a biomarker in HL, a systematic review was conducted to collect and evaluate the current knowledge of miRNAs functioning as diagnostic and prognostic biomarkers in HL. A systematic literature search was conducted to retrieve relevant articles from five different electronic databases up to April 2018. Search terms included ‘Hodgkin’s lymphoma’, ‘microRNA’, ‘prognostic biomarker’ and ‘diagnostic biomarker’. The selected articles were assessed using CROWE critical appraisal tool. The literature search identified a total of 1362 articles from which a final 20 relevant studies were included. In total, 118 miRNAs with significance to HL were observed. 85 miRNAs were reported with regards to its expression and associated pathogenesis. 66 miRNAs were found to be up-regulated in HL, while 18 were found down-regulated. 20 miRNAs were correlated to prognosis. One study reported higher expression of miRNAs based on the expression in plasma extracellular vesicle, and the finding was found to be reliable for therapy response. Three top most important miRNAs were also depicted in this review, which may have significant role in HL pathogenesis. In conclusion, the relevant information on miRNAs particularly in monitoring treatment response is hoped to benefit the treatment advances in HL in the future.

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Published

2019-08-08

How to Cite

NIK IZHAR , N. N. ., MOHAMMAD , M. ., ABDUL RAHMAN , R. ., & ZAINUDDIN , N. . (2019). MICRORNA AS A POTENTIAL BIOMARKER IN THE DIAGNOSIS AND PROGNOSIS OF HODGKIN’S LYMPHOMA: A SYSTEMATIC REVIEW. INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES, 3(2), 694–724. Retrieved from https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/260

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