Synergistic Interaction Between Combination of Existing Therapy with Polyphenols in Several Human Diseases: A Review

Authors

  • Amira Raudhah Abdullah Faculty of Medicine and Health Science, Universiti Islam Sains Malaysia, Persiaran Ilmu, Putra Nilai, 71800 Nilai, Negeri Sembilan, Malaysia
  • Hermizi Hapidin Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia

DOI:

https://doi.org/10.31436/jop.v3i2.180

Keywords:

polyphenols, synergistic effects, anti-cancer, anti-microbial, anti-diabetic

Abstract

The complicated pathology of current diseases requires an intricate treatment. Today, current application of individual single-target drugs or therapeutic approaches is inadequate to target these diseases not to mentioned perceived shortcomings and presented with numerous adverse effects. The extensive and successful documented findings in natural product researches urges the need to make use of these knowledge in the development of new generation of medicine. Polyphenols are compounds naturally derived from plants and have been describe in many research to have tremendous medical benefit. Therefore, a synergistic combination of readily available drugs or other therapeutic approaches is a favourable approach to enhance efficacy, overcome toxicity and optimize safety. The objective of this review is to describe the synergistic effects between the combination of a variety of polyphenols with synthetic drugs or other therapeutic approaches which can help to improve therapeutic efficacy subsequently minimize the adverse effects of a substance targeted in various diseases focusing mainly on cancer, diabetic, microbial infections and tissue regeneration along with their underlying mechanism.

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Published

2023-07-31

How to Cite

Abdullah, A. R., & Hapidin, H. (2023). Synergistic Interaction Between Combination of Existing Therapy with Polyphenols in Several Human Diseases: A Review. Journal of Pharmacy, 3(2), 86–102. https://doi.org/10.31436/jop.v3i2.180

Issue

Section

Review Articles