A Review on Complete Freund’s Adjuvant-Induced Arthritic Rat Model: Factors Leading to its Success

Che Aishah Nazariah Ismail; Ain' Sabreena Mohd Noh; Dai Chuan Tan; Nurul Ajilah Mohamed Khir; Nazlahshaniza Shafin

doi:10.31436/imjm.v21i4.2026

A Review on Complete Freund’s Adjuvant-Induced Arthritic Rat Model: Factors Leading to its Success

Authors

Che Aishah Nazariah Ismail Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia
Ain' Sabreena Mohd Noh Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia
Dai Chuan Tan Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Nurul Ajilah Mohamed Khir International Medical School, Management and Science University, Shah Alam, Selangor, Malaysia
Nazlahshaniza Shafin Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia

DOI:

https://doi.org/10.31436/imjm.v21i4.2026

Keywords:

Complete Freund's Adjuvant, mycobacterium, arthritis, inflammation, animal model

Abstract

Arthritis-induced adjuvant (AIA) is an established animal model reflecting several clinical manifestations of human arthritis. It provides more understanding of pathogenesis and pathways involved in arthritic development and for testing various treatment modalities. Complete Freund’s adjuvant (CFA) is one of the most known algogenic agents used to develop AIA rodent model. Its wide application increases understanding of CFA effects locally and systemically following adjuvant-containing mycobacterium exposure in-vivo. This study aims to review possible factors involved in producing a successful CFA-induced arthritic rat model. We conducted a review of previous studies to determine critical factors to be emphasized. Since arthritis can be classified as gout, osteoarthritis, and rheumatoid arthritis, among others, factors that should be assessed include different dosage and volume, injection site, remission, arthritic and animal gender, and strain selections to successfully develop an arthritic rat model.

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Published

01.10.2022

How to Cite

Ismail, C. A. N., Mohd Noh, A. S., Tan, D. C., Mohamed Khir, N. A., & Shafin, N. (2022). A Review on Complete Freund’s Adjuvant-Induced Arthritic Rat Model: Factors Leading to its Success. IIUM Medical Journal Malaysia, 21(4). https://doi.org/10.31436/imjm.v21i4.2026

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Issue

Vol. 21 No. 4 (2022): IIUM Medical Journal Malaysia - October 2022

Section

Review Article

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