Insight of Mechanism and Signaling Pathway in Pathogenesis of Diabetic Neuropathy: A Review: Pathogenesis of Diabetic Neuropathy

Norhamidar  Ab Hamid; Norsuhana Omar; Che Aishah Nazariah Ismail; Idris Long

doi:10.31436/imjm.v20i4.1947

Insight of Mechanism and Signaling Pathway in Pathogenesis of Diabetic Neuropathy: A Review

Pathogenesis of Diabetic Neuropathy

Authors

Norhamidar Ab Hamid School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang kerian, Kelantan
Norsuhana Omar Department of Physiology, School of Medical Science, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kota Bharu, Kelantan
Che Aishah Nazariah Ismail Department of Physiology, School of Medical Science, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kota Bharu, Kelantan
Idris Long School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kota Bharu, Kelantan

DOI:

https://doi.org/10.31436/imjm.v20i4.1947

Keywords:

Diabetic neuropathy, hyperglycemia, signaling pathways, glucotoxicity, vascular dysfunction, oxidative stress

Abstract

Diabetic neuropathy (DN) is a common chronic microvascular complication of diabetes mellitus. The features of DN include allodynia, hyperalgesia, abnormal or loss of sensation of nerve fibers. The clinical features will contribute to poor quality of life, disrupt sleep, lead to depression, and increases mortality. Current drug treatments have been shown to alleviate the symptoms of DN but failed to treat the underlying causes of DN. Therefore, a better understanding of the molecular mechanisms underlying the development and progression of DN is needed for early diagnosis and intervention and understanding the failure of existing treatments. Identification of potential mechanisms is critical for better prediction of progression and for designing preventive therapies. DN's exact pathogenesis is incomplete, although it is understood that its multifunctional dysfunction involving many signaling pathways. This review summarized the common deterioration of signaling pathways and mechanisms involved in DN pathogenesis.

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Published

01.10.2021

How to Cite

Ab Hamid, N. ., Omar, N., Ismail, C. A. N., & Long, I. (2021). Insight of Mechanism and Signaling Pathway in Pathogenesis of Diabetic Neuropathy: A Review: Pathogenesis of Diabetic Neuropathy. IIUM Medical Journal Malaysia, 20(4). https://doi.org/10.31436/imjm.v20i4.1947

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Issue

Vol. 20 No. 4 (2021): IIUM Medical Journal Malaysia - October 2021

Section

Review Article

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