Model of a critical size defect in the New Zealand White rabbit’s tibia


  • Che Nor Zarida Che Seman
  • Zamzuri Zakaria
  • Mohamed Azril Mohamed Amin
  • Mohd Shukrimi Awang
  • Nazri Mohd Yusof
  • Zunariah Buyong



Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study. Results: This alternative method created good CSD with less bleeding from the muscle observed. No mortality on other surgical complications were observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New Zealand White rabbits.


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How to Cite

Che Seman, C. N. Z. ., Zakaria, Z. ., Mohamed Amin, . M. A. ., Awang, M. S. ., Mohd Yusof, N. ., & Buyong, . Z. . (2016). Model of a critical size defect in the New Zealand White rabbit’s tibia. IIUM Medical Journal Malaysia, 15(1).



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