Extraction of Local Artocarpus heterophyllus (Jackfruit) Seeds and Its Effects on the Migration of Oral Squamous Cell Carcinoma (OSCC)

Authors

  • Annur Sofea Fitriah Binti Rizbi Department of Nutrition Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Pahang, Malaysia
  • Mahfuzah Elmuhammady Binti Abu Bakar
  • Engku Nasiha Binti Engku Ngah Sayuddin
  • Muhamad Ashraf Rostam Department of Nutrition Sciences, International Islamic University, Malaysia

Abstract

Background: Oral squamous cell carcinoma (OSCC) is an aggressive cancer with poor treatment outcomes. This study investigates the anti-migratory effects of aqueous Artocarpus heterophyllus (jackfruit) seed extract and purified jacalin on ORL-48 OSCC cells.

Methods: Jackfruit seeds were subjected to aqueous extraction. ORL-48 cells were cultured and treated with crude extract, jacalin, cisplatin, and untreated control. Scratch assay was performed and wound closure was quantified with ImageJ.

Results: The crude extract demonstrated the lowest wound closure (6.37%), followed by jacalin (13.45%), cisplatin (20.80%), and control (25.98%). Although not statistically significant, the crude extract showed the strongest inhibitory trend.

Conclusion: The aqueous extract of jackfruit seeds exhibited potential anti-migratory properties against OSCC cells, warranting further exploration in oral cancer therapy.

Keywords: jackfruit seeds; oral squamous cell carcinoma; cell migration; jacalin; aqueous extract

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Published

2025-12-12

How to Cite

Annur Sofea Fitriah Binti Rizbi, Mahfuzah Elmuhammady Binti Abu Bakar, Engku Nasiha Binti Engku Ngah Sayuddin, & Muhamad Ashraf Rostam. (2025). Extraction of Local Artocarpus heterophyllus (Jackfruit) Seeds and Its Effects on the Migration of Oral Squamous Cell Carcinoma (OSCC). International Journal of Allied Health Sciences, 9(SUPP3). Retrieved from https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/1066

Issue

Vol. 9 No. SUPP3 (2025): Kulliyyah of Allied Health Sciences Special Issue: Early detection, Prevention and Intervention in Allied Health

Section

Original Articles and Reviews