• Rosnani Hasham Universiti Teknologi Malaysia
  • Nagainthini Maniarasu Department of Bioprocess and Polymer Engineering, Universti Teknologi Malaysia
  • Khairunadwa Jemon Department of Biological Sciences, Faculty of Science, Universiti Teknologi Malaysia.
  • Nurriza Abd Latif Department of Biological Sciences, Faculty of Science, Universiti Teknologi Malaysia.
  • Hasnah Bahari Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia.


Rosmarinic acid, Orthosiphon aristatus, wound healing, anti-aging, PI3K/Akt/mTOR signalling pathway


Rosmarinic acid is a phenolic compound procured from the species of the Boraginaceae and the Lamiaceae subfamily Nepetoideae. Rosmarinic acid has numeral of biologically stimulating properties. Rosmarinic acid is a chemical constituent which is a major compound found in Orthosiphon aristatus leaves and it is about 5-10% w/w in the ethanolic extract of the leaves. The skin is the largest organ of a human body and it is frequently impacted by a variety of environmental conditions, such as skin infections, skin oxidation, wounds, UV radiation exposure and skin aging. In both physiological and pathological conditions, the phosphatidylinositol 3-kinase (PI3K) / protein kinase B (AKT) enzyme aids in the preservation and repair of the epidermis, dermis, and hair follicles layer of the skin. PI3K/Akt manages cell proliferation, differentiation, migration as well as angiogenesis and metabolism. This review paper compiles, summarizes and considers on skin regenerative and wound healing.


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How to Cite

Hasham, R., Maniarasu, N., Jemon, K. ., Abd Latif, N. ., & Bahari, H. (2023). A REVIEW ON ROSMARINIC ACID RICH EXTRACT FOR SKIN REGENERATION THROUGH RAPAMYCIN SIGNALING PATHWAY. Chemical and Natural Resources Engineering Journal (Formally Known As Biological and Natural Resources Engineering Journal), 7(1), 1–9. Retrieved from https://journals.iium.edu.my/bnrej/index.php/bnrej/article/view/85