Tuberculous Encephalopathy Mimicking Limbic Encephalitis and Large Intraparenchymal Mass: A Challenge In Diagnosis
Tuberculosis of central nervous system (CNS TB) being endemic in Malaysia, most commonly presents as tuberculoma or meningitis. Less commonly, this specific disease entity presents as cerebritis, miliary form, encephalitis and large intraparenchymal mass. At the cellular level, it was even postulated that the pathogenesis of the most common form of CNS TB is way different from the rarer form of encephalitis. Parenchymal involvement of CNS TB is primarily believed as a result of leptomeningeal/ ependymal extension or gross occlusion of basal arteries due to exudates and arteritis. However, the pathogenesis of TB encephalitis was postulated to result from type IV direct (allergic type) hypersensitivity which is similar to other demyelinating diseases at present. Here, we highlight an extremely rare imaging manifestation of CNS TB, which impersonates limbic encephalitis and large intraparenchymal mass imposing a diagnostic dilemma.
How to Cite
All material submitted for publication is assumed to be submitted exclusively to the IIUM Medical Journal Malaysia (IMJM) unless the contrary is stated. Manuscript decisions are based on a double-blinded peer review process. The Editor retains the right to determine the style and if necessary, edit and shorten any material accepted for publication.
IMJM retain copyright to all the articles published in the journal. All final ‘proof’ submissions must be accompanied by a completed Copyright Assignment Form, duly signed by all authors. The author(s) or copyright owner(s) irrevocably grant(s) to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the research article in its entirety or in part, in any format or medium, provided that no substantive errors are introduced in the process, proper attribution of authorship and correct citation details are given, and that the bibliographic details are not changed. If the article is reproduced or disseminated in part, this must be clearly and unequivocally indicated.