Cytotoxicity and Antifungal Properties of Hydroxychavicol Against Trichophyton rubrum

P. M.  Ridzuan; Nasir  Mohamad; Salwani  Ismail; Nor Iza  A. Rahman; Hairul Aini  H.; B.  Zunariah; M. H.  Norazian; Baharudin  Roesnita

doi:10.31436/imjm.v17i1.288

Cytotoxicity and Antifungal Properties of Hydroxychavicol Against Trichophyton rubrum

Authors

P. M. Ridzuan
Nasir Mohamad
Salwani Ismail
Nor Iza A. Rahman
Hairul Aini H.
B. Zunariah
M. H. Norazian
Baharudin Roesnita

DOI:

https://doi.org/10.31436/imjm.v17i1.288

Abstract

Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte (3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles. Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may potentially be used as an alternative therapeutic agent against T. rubrum infections.

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Published

01.04.2018

How to Cite

Ridzuan, P. M., Mohamad, N. ., Ismail, . S. ., A. Rahman, N. I., H., H. A. ., Zunariah, . B. ., Norazian, . M. H. ., & Roesnita, . B. . (2018). Cytotoxicity and Antifungal Properties of Hydroxychavicol Against Trichophyton rubrum. IIUM Medical Journal Malaysia, 17(1). https://doi.org/10.31436/imjm.v17i1.288

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Issue

Vol. 17 No. 1 (2018): International Medical Journal Malaysia - April 2018

Section

Original Articles

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