A review of black seed extract as an agent in the wound healing process
Keywords:Nigella Sativa, black seed, wound healing
Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment.
Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results.
Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis.
Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.
Ab Rahman, M. R., Abdul Razak, F., & Mohd Bakri, M. (2014). Evaluation of Wound Closure Activity of Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum Extracts on Scratched Monolayer of Human Gingival Fibroblasts. Evidence-Based Complementary and Alternative Medicine, 2014, 1–9. https://doi.org/10.1155/2014/190342
Abd Elrahman, S. M., Younes, S. A., & Kawana, K. Y. (2019). Evaluation of Nigella Sativa on Socket Healing in Rabbits. Alexandria Dental Journal, 44(3), 60–64. https://doi.org/10.21608/adjalexu.2019.63559
Abu-Al-Basal M. A. (2011). Influence of Nigella sativa fixed oil on some blood parameters and histopathology of skin in staphylococcal-infected BALB/c mice. Pakistan journal of biological sciences: PJBS, 14(23), 1038–1046. https://doi.org/10.3923/pjbs.2011.1038.1046
Abuzinadah, O. (2009). Using Nigella sativa Oil to Treat and Heal Chemical Induced Wound of Rabbit Skin. Journal of King Abdulaziz University-science, 21, 335-346.
Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. A., Damanhouri, Z. A., & Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337–352. https://doi.org/10.1016/S2221-1691(13)60075-1
Ahmed, I. H., Awad, M. A., El-Mahdy, M., Gohar, H. M., & Ghanem, A. M. (1995). The effect of some medicinal plant extracts on wound healing in farm animals. Assiut Veterinary Medical Journal, 32(64), 236-244.
Al-Gaban, N. M., Ghani, B. A., & Kadhim, E. F. (2017). Evaluation of Topical Application of Propolis, Black Seeds, and Honey on Oral Mucosal Healing in Rabbits (Histological and Immunohistochemical Study on TGF-?3). International Journal of Science and Research (IJSR), 6(2), 1445–1450. https://doi.org/10.21275/ART20164558
Ali, A., Mohebbullah, M., Shahid, M. A., Alam, S., Uddin, M. N., Miah, M. S., Jamal, M. S. I., & Khan, M. S. (2020). PVA-Nigella Sativa nanofibrous mat: antibacterial efficacy and wound healing potentiality. Journal of the Textile Institute, 0(0), 1–11. https://doi.org/10.1080/00405000.2020.1831168
Apaydin, Y. B., & Gedikli, S. (2019). Wound healing effects of Nigella sativa L. essential oil in streptozotocin-induced in diabetic rats. GSC Biological and Pharmaceutical Sciences, 7(3), 030–039. https://doi.org/10.30574/gscbps.2019.7.3.0095
Cui, X., Gong, J., Han, H., He, L., Teng, Y., Tetley, T., Sinharay, R., Chung, K. F., Islam, T., Gilliland, F., Grady, S., Garshick, E., Li, Z., & Zhang, J. (2018). Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens. Journal of Thoracic Disease, 10(5), 3088–3197. https://doi.org/10.21037/jtd.2018.05.92
Davies, J. E., & Hosseini, M. M. (2000). Histodynamics of endosseous wound healing. Bone engineering, 1(1), 1-14. Retrieved from https://www.researchgate.net/profile/John-Davies11/publication/255964870_Histodynamics_of_Endosseous_Wound_Healing/links/54dd0e120cf28a3d93f88e92/Histodynamics-of-Endosseous-Wound-Healing.pdf
Davoudi-Kiakalayeh, A., Mohammadi, R., Pourfathollah, A. A., Siery, Z., & Davoudi-Kiakalayeh, S. (2017). Alloimmunisation in thalassemia patients: New insight for healthcare. International Journal of Preventive Medicine, 8, 1–7. https://doi.org/10.4103/ijpvm.IJPVM
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T. (2017). Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. International Wound Journal, 14(1), 89–96. https://doi.org/10.1111/iwj.12557
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., ... & Georgopoulos, N. T. (2017). Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS?modulating technologies for augmentation of the healing process. International wound journal, 14(1), 89-96.
Elgohary, H. M., Al Jaouni, S. K., & Selim, S. A. (2018). Effect of ultrasound-enhanced Nigella sativa seeds oil on wound healing: An animal model. Journal of Taibah University Medical Sciences, 13(5), 438–443. https://doi.org/10.1016/j.jtumed.2018.02.008
Etulain, J. Platelets in wound healing and regenerative medicine. Platelets. (2018), 29, 556–568. https://doi.org/10.1080/09537104.2018.1430357
Halawani, E. (2009). Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Antibiotics. Advances in Biological Research, 3(56), 148–152.
Javadi, S. M. R., Hashemi, M., Mohammadi, Y., MamMohammadi, A., Sharifi, A., & Makarchian, H. R. (2018). Synergistic effect of honey and nigella sativa on wound healing in rats. Acta Cirurgica Brasileira, 33(6), 518–523. https://doi.org/10.1590/s0102-865020180060000006
Kumanda?, A., Karsli, B., Kürüm, A., Çinar, M., & Elma, E. (2020). Comparison of the effects of zinc-silver cream and nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Universitesi Veteriner Fakultesi Dergisi, 67(1), 33–40. https://doi.org/10.33988/auvfd.563491
MacEwan, M. R., MacEwan, S., Kovacs, T. R., & Batts, J. (2017). What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold. Cureus, 9(10). https://doi.org/10.7759/cureus.1736
Mandal, A. M., Sene, P., & Manggang, R. K. J. (2015). A Review on Indian Medicinal Plants and Their Role in Wound Healing Activity. World Journal of Pharmaceutical Research, 4(6), 2204-2224.
Mastuti, S., Hadi, D. T., & Chodidjah, C. (2017). Nigella Sativa Seed Extract Ointment Increasing the Amount of Healing Fibroblast and Collagen on BALB/c Mice. Sains Medika, 8(1), 15. https://doi.org/10.26532/sainsmed.v8i1.1006
Mayet, N., Choonara, Y. E., Kumar, P., Tomar, L. K., Tyagi, C., Du Toit, L. C., & Pillay, V. (2014). A comprehensive review of advanced biopolymeric wound healing systems. Journal of pharmaceutical sciences, 103(8), 2211-2230. https://doi.org/10.1002/jps.24068
Mohammed, S. J., Amin, H. H. H., Aziz, S. B., Sha, A. M., Hassan, S., Abdul Aziz, J. M., & Rahman, H. S. (2019). Structural Characterization, Antimicrobial Activity, and in Vitro Cytotoxicity Effect of Black Seed Oil. Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/6515671
Mirazi, N., Nourbar, E., Yari, S., Rafieian-Kopaei, M., & Nasri, H. (2019). Effect of hydroethanolic extract of Nigella sativa L. on skin wound healing process in diabetic male rats. International Journal of Preventive Medicine, 10(1), 18. https://doi.org/10.4103/ijpvm.ijpvm_276_18
Nourbar, E., Mirazi, N., Yari, S., Mahmoud, Rafieian?Kopaei, & Nasri, H. (2019). Effect of Hydroethanolic Extract of Nigella sativa L. on Skin Wound Healing Process in Diabetic Male Rats. International Journal of Preventive Medicine, 1–7. https://doi.org/10.4103/ijpvm.IJPVM
Rajabian, A., & Hosseinzadeh, H. (2020). Dermatological Effects of Nigella sativa and Its Constituent, Thymoquinone. In Nuts and Seeds in Health and Disease Prevention, 329-355. Elsevier Inc. https://doi.org/10.1016/b978-0-12-818553-7.00024-3
Razavi, B. M., & Hosseinzadeh, H. (2014). A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. Journal of Endocrinological Investigation, 37(11), 1031-1040.
Rohmah, D. I., & Suprayitno, E. (2020). Effect of Addition of Black Cumin Seed Oil (Nigella sativa) as a Source of Omega-6 on Cork Albumin Powder (Channa Striata) for Wound Closure. International Journal of Scientific and Research Publications (IJSRP), 10(7), 656–662. https://doi.org/10.29322/ijsrp.10.07.2020.p10371
Rowi?ski, R., Kozakiewicz, M., K?dziora-Kornatowska, K., Hübner-Wo?niak, E., & K?dziora, J. (2013). Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity. Experimental Gerontology, 48(11), 1141-1146. https://doi.org/10.1016/j.exger.2013.07.010
Sallehuddin, N., Nordin, A., Idrus, R. B. H., & Fauzi, M. B. (2020). Nigella sativa and its active compound, thymoquinone, accelerate wound healing in an in vivo animal model: A comprehensive review. International Journal of Environmental Research and Public Health, 17(11), 1–17. https://doi.org/10.3390/ijerph17114160
Sahak, M. K. A., Kabir, N., Abbas, G., Draman, S., Hashim, N. H., & Hasan Adli, D. S. (2016). The Role of Nigella sativa and Its Active Constituents in Learning and Memory. Evidence-Based Complementary and Alternative Medicine, 2016, 1–6. https://doi.org/10.1155/2016/6075679
Sarkhail, P., Esmaily, H., Baghae, A., Shafiee, A., Abdollahi, M., & Sarkheil, P. (2011). Evaluation of Burn Healing Activity of Black Seed Oil in Rats. Planta Medica, 77(12), 34–39. https://doi.org/10.1055/s-0031-1282650
Sari, Y., Purnawan, I., Kurniawan, D. W., & Sutrisna, E. (2018). A comparative study of the effects of nigella sativa oil gel and aloe Vera gel on wound healing in diabetic rats. Journal of Evidence-Based Integrative Medicine, 23, 1–6. https://doi.org/10.1177/2515690X18772804
Selçuk, C. T., Durgun, M., Tekin, R., Yolbas, L., Bozkurt, M., Akçay, C., ... & Basarali, M. K. (2013). Evaluation of the effect of thymoquinone treatment on wound healing in a rat burn model. Journal of Burn Care & Research, 34(5), e274-e281. https://doi.org/10.1097/BCR.0b013e31827a2be1
Singh, S., Young, A., & McNaught, C.-E. (2017). The physiology of wound healing. Surgery (Oxford), 35(9), 473–477. https://doi.org/10.1016/j.mpsur.2017.06.004
Sinno, H., & Prakash, S. (2013). Complements and the Wound Healing Cascade: An Updated Review. Plastic Surgery International, 2013, 1–7. https://doi.org/10.1155/2013/146764
Trisnawati, R. (2018). The Effect of Thymoquinone Extract of Black Seeds Toward Socket New Blood Vessels Formation Process After Extraction in Diabetic-Induced Rats. In Research Article Journal of Diabetes and Cholesterol Metabolism (Vol. 2, Issue 1). DCM. Retrieved from http://rpdemos.net/clients/hendunadmin/admin/uploads/source/DCM/DCM-18-2-110.pdf
Turhan, Y. ?., Ar?can, M., Karaduman, Z. O., Turhal, O., Gams?zkan, M., Ayd?n, D., & Ozkan, K. (2019). Comparison of the Effects of Nigella sativa Oil and Nano-silver on Wound Healing in an Experimental Rat Model. Iranian Red Crescent Medical Journal, 10(10), 1259–1272. https://doi.org/10.5812/ircmj.84650.
Vigani, A., & Culler, C. A. (2017). Systemic and Local Management of Burn Wounds. Veterinary Clinics of North America: Small Animal Practice, 47(6), 1149–1163. https://doi.org/10.1016/j.cvsm.2017.06.003
Yaman, I., Durmus, A. S., Ceribasi, S., & Yaman, M. (2010). Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Veterinarni Medicina, 55(12), 619–624. https://doi.org/10.17221/2948-VETMED
Yimer, E. M., Tuem, K. B., Karim, A., Ur-Rehman, N., & Anwar, F. (2019). Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. Evidence-Based Complementary and Alternative Medicine, 2019, 1–16. https://doi.org/10.1155/2019/1528635
Yusmin, A., & Ahmad, N. (2017). Effect of thymoquinone on wound healing in alloxan-induced diabetic rats. Asian Journal of Pharmaceutical and Clinical Research, 10(9), 242–245. https://doi.org/10.22159/ajpcr.2017.v10i9.18951
How to Cite
Copyright (c) 2021 IIUM Press
This work is licensed under a Creative Commons Attribution 4.0 International License.
Journal of Pharmacy at https://journals.iium.edu.my/ktn/index.php/jp is licensed under a Creative Commons Attribution 4.0 International License.