Avocado Fruit and Leaf Bioactive Phytochemicals and Cosmeceutical Applications: A Scoping Review

Ling Li  Yeoh; Xin Nee  Lee; Wen Ying  Lee; Bey Hing Goh; Sathiya Maran

doi:10.31436/jop.v4i2.302

Authors

Ling Li Yeoh 1. School of Pharmacy, Monash University, Jalan Lagoon Selatan, 47500 Bandar Sunway. Selangor Darul Ehsan
Xin Nee Lee 1. School of Pharmacy, Monash University, Jalan Lagoon Selatan, 47500 Bandar Sunway. Selangor Darul Ehsan
Wen Ying Lee 1. School of Pharmacy, Monash University, Jalan Lagoon Selatan, 47500 Bandar Sunway. Selangor Darul Ehsan
Bey Hing Goh Department of Biological Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Selangor Darul Ehsan
Sathiya Maran School of Pharmacy, Monash University, Jalan Lagoon Selatan, 47500 Bandar Sunway. Selangor Darul Ehsan https://orcid.org/0000-0001-5617-901X

DOI:

https://doi.org/10.31436/jop.v4i2.302

Keywords:

avocado, extraction, bioactive compound, cosmeceutical, skin, antioxidant activity

Abstract

The cosmeceutical industry has been blooming over the years, necessitating a demand for safe and effective options. Fruit bioactive compounds are reported as safe for human health and broadly effective alternatives with less adverse effects. Avocado (Persea americana Mill.) is a tropical fruit rich in phytonutrients and lipid-soluble bioactive compounds. These compounds have been reported to have various potential health benefits, including improving skin health. This scoping review investigated the bioactive compounds of avocados that were reported to confer beneficial activities on the skin. Published data between August 1982 till February 2022 were extracted from Ovid Medline, Scopus, Pubmed, SciFinder and Web of Science. A total of 307 published articles were identified using the search terms, of which 31 full articles were reviewed and appraised in this synthesis. This comprehensive scoping review examined the cosmeceutical activities of bioactive phytochemicals found in avocado (Persea americana Mill.) outlining their mechanisms of action. The review highlighted the antioxidant, antimicrobial, anti-inflammatory, wound healing, anti-tyrosinase, and anti-aging properties of avocado extracts. Acetone extracts, especially from seeds, showed the highest antioxidant capacity and were also effective in antimicrobial activities. Methanol extracts demonstrated significant anti-inflammatory effects. Furthermore, bioactive compounds from avocados were found to enhance wound healing and anti-aging effects, such as increasing collagen production and improving skin hydration and elasticity. This scoping review provides a comprehensive collection of evidence and critically appraises recent literature on bioactive compounds of Avocado and extraction solvents and potential cosmeceutical applications.

References

Alves, A. Q., da Silva Jr, V. A., Góes, A. J. S., Silva, M. S., de Oliveira, G. G., Bastos, I. V. G. A., de Castro Neto, A. G., & Alves, A. J. (2019). The fatty acid composition of vegetable oils and their potential use in wound care. Advances in skin & wound care, 32(8), 1-8.

Borghi, A., Corazza, M., Minghetti, S., Toni, G., & Virgili, A. (2015). Avocado and soybean extracts as active principles in the treatment of mild?to?moderate vulvar lichen sclerosus: results of efficacy and tolerability. Journal of the European Academy of Dermatology and Venereology, 29(6), 1225-1230.

de Oliveira, A. P., Franco Ede, S., Rodrigues Barreto, R., Cordeiro, D. P., de Melo, R. G., de Aquino, C. M., AA, E. S., de Medeiros, P. L., da Silva, T. G., Góes, A. J., & Maia, M. B. (2013). Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats. Evid Based Complement Alternat Med, 2013, 472382. https://doi.org/10.1155/2013/472382

de Oliveira, A. P., Franco, E. d. S., Rodrigues Barreto, R., Cordeiro, D. P., de Melo, R. G., de Aquino, C. M. F., e Silva, A. A. R., de Medeiros, P. L., da Silva, T. G., Góes, A. J. d. S., & Maia, M. B. d. S. (2013). Effect of Semisolid Formulation of Persea Americana Mill (Avocado) Oil on Wound Healing in Rats. Evidence-Based Complementary and Alternative Medicine, 2013, 472382. https://doi.org/10.1155/2013/472382

Deuschle, V. C., Brusco, I., Piana, M., Faccin, H., de Carvalho, L. M., Oliveira, S. M., & Viana, C. (2019). Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice. Inflammopharmacology, 27(2), 323-338.

Donnarumma, G., Buommino, E., Baroni, A., Auricchio, L., Filippis, A. D., Cozza, V., Msika, P., Piccardi, N., & Tufano, M. A. (2007). Effects of AV119, a natural sugar from avocado, on Malassezia furfur invasiveness and on the expression of HBD?2 and cytokines in human keratinocytes. Experimental dermatology, 16(11), 912-919.

Dreher, M. L., & Davenport, A. J. (2013). Hass avocado composition and potential health effects. Crit Rev Food Sci Nutr, 53(7), 738-750. https://doi.org/10.1080/10408398.2011.556759

Ekom, S. E., & Kuete, V. (2022). Methanol extract from the seeds of Persea americana displays antibacterial and wound healing activities in rat model. Journal of Ethnopharmacology, 282, 114573.

Felmingham, C., Chan, L., Doyle, L. W., & Veysey, E. (2020). The Vulval Disease Quality of Life Index in women with vulval lichen sclerosus correlates with clinician and symptom scores. Australasian Journal of Dermatology, 61(2), 110-118. https://doi.org/https://doi.org/10.1111/ajd.13197

Ferreira da Vinha, A., Moreira, J., & Barreira, S. (2013). Physicochemical parameters, phytochemical composition and antioxidant activity of the algarvian avocado (Persea americana Mill.). Journal of Agricultural Science, 5(12), 100-109.

Forero-Doria, O., García, M. F., Vergara, C. E., & Guzman, L. (2017). Thermal analysis and antioxidant activity of oil extracted from pulp of ripe avocados. Journal of Thermal Analysis and Calorimetry, 130(2), 959-966.

García-Villegas, A., Rojas-García, A., Villegas-Aguilar, M. D. C., Fernández-Moreno, P., Fernández-Ochoa, Á., Cádiz-Gurrea, M. d. l. L., Arráez-Román, D., & Segura-Carretero, A. (2022). Cosmeceutical Potential of Major Tropical and Subtropical Fruit By-Products for a Sustainable Revalorization. Antioxidants (Basel, Switzerland), 11(2), 203. Retrieved 2022/01//, from http://europepmc.org/abstract/MED/35204085

https://doi.org/10.3390/antiox11020203

https://europepmc.org/articles/PMC8868306

https://europepmc.org/articles/PMC8868306?pdf=render

Henning, S. M., Guzman, J. B., Thames, G., Yang, J., Tseng, C.-H., Heber, D., Kim, J., & Li, Z. (2022). Avocado Consumption Increased Skin Elasticity and Firmness in Women - A Pilot Study. Journal of cosmetic dermatology, 21(9), 4028-4034. https://doi.org/https://doi.org/10.1111/jocd.14717

Henning, S. M., Guzman, J. B., Thames, G., Yang, J., Tseng, C. H., Heber, D., Kim, J., & Li, Z. (2022). Avocado Consumption Increased Skin Elasticity and Firmness in Women?A Pilot Study. Journal of cosmetic dermatology.

Hürkul, M.-M., Sar?alt?n, S.-Y., Köro?lu, A., & Çoban, T. (2021). In vitro inhibitory potential of avocado fruits, Persea americana (Lauraceae) against oxidation, inflammation and key enzymes linked to skin diseases. Revista de Biología Tropical, 69(2), 472-481.

Husein El Hadmed, H., & Castillo, R. F. (2016). Cosmeceuticals: peptides, proteins, and growth factors. J Cosmet Dermatol, 15(4), 514-519. https://doi.org/10.1111/jocd.12229

Kosin?ska, A., Karamac?, M., Estrella, I., Herna?ndez, T., Bartolomé, B., & Dykes, G. A. (2012). Phenolic compound profiles and antioxidant capacity of Persea americana Mill. peels and seeds of two varieties. Journal of agricultural and food chemistry, 60(18), 4613-4619.

Lagoa, R., Silva, J., Rodrigues, J. R., & Bishayee, A. (2020). Advances in phytochemical delivery systems for improved anticancer activity. Biotechnology advances, 38, 107382.

Laksmiani, N. P. L., Sanjaya, I. K. N., & Leliqia, N. P. E. (2020). The activity of avocado (Persea americana Mill.) seed extract containing catechin as a skin lightening agent. J Pharm Pharmacogn Res, 8, 449-456.

Lamaud, E., Huc, A., & Wepierre, J. (1982). Effects of avocado and soya bean lipidic non?saponifiables on the components of skin connective tissue after topical application in the hairless rat: biophysical and biomechanical determination. International journal of cosmetic science, 4(4), 143-152.

Lin, T.-K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences, 19(1), 70.

Lister, I., Amiruddin, H. L., Fachrial, E., & Girsang, E. (2021). Anti-Aging Effectiveness of Avocado Peel Extract Ointment (Persea Americana Mill.) against Hydration, Collagen, and Elasticity Levels in Wistar Rat. Journal of Pharmaceutical Research International, 173-184.

Melgar, B., Dias, M. I., Ciric, A., Sokovic, M., Garcia-Castello, E. M., Rodriguez-Lopez, A. D., Barros, L., & Ferreira, I. C. (2018). Bioactive characterization of Persea americana Mill. by-products: A rich source of inherent antioxidants. Industrial Crops and Products, 111, 212-218.

Moldovan, M. L., Ionu?, I., & Bogdan, C. (2021). Cosmetic products containing natural based emollients for restoring impaired skin barrier: formulation and in vivo evaluation. Farmacia, 69(1), 129-134.

Mwinga, J., Makhaga, N., Aremu, A., & Otang-Mbeng, W. (2019). Botanicals used for cosmetic purposes by Xhosa women in the Eastern Cape, South Africa. South African Journal of Botany, 126, 4-10.

Naeimifar, A., Ahmad Nasrollahi, S., Samadi, A., Talari, R., Sajad Ale?nabi, S., Massoud Hossini, A., & Firooz, A. (2020). Preparation and evaluation of anti?wrinkle cream containing saffron extract and avocado oil. Journal of cosmetic dermatology, 19(9), 2366-2373.

Nguyen, T.-V.-L., Nguyen, Q.-D., Nguyen, N.-N., & Nguyen, T.-T.-D. (2021). Comparison of Phytochemical Contents, Antioxidant and Antibacterial Activities of Various Solvent Extracts Obtained from ‘Maluma’Avocado Pulp Powder. Molecules, 26(24), 7693.

Nilforoushzadeh, M. A., Amirkhani, M. A., Zarrintaj, P., Salehi Moghaddam, A., Mehrabi, T., Alavi, S., & Mollapour Sisakht, M. (2018). Skin care and rejuvenation by cosmeceutical facial mask. Journal of cosmetic dermatology, 17(5), 693-702.

Oryan, A., Mohammadalipour, A., Moshiri, A., & Tabandeh, M. R. (2015). Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling. International Wound Journal, 12(6), 674-685.

Pandey, H., & Kumar, S. (2021). Butylated hydroxytoluene and Butylated hydroxyanisole induced cyto-genotoxicity in root cells of Allium cepa L. Heliyon, 7(5), e07055. https://doi.org/10.1016/j.heliyon.2021.e07055

Paoletti, I., Buommino, E., Tudisco, L., Baudouin, C., Msika, P., Tufano, M. A., Baroni, A., & Donnarumma, G. (2010). Patented natural avocado sugars modulate the HBD-2 expression in human keratinocytes through the involvement of protein kinase C and protein tyrosine kinases. archives of dermatological research, 302(3), 201-209.

Poljšak, N., Kreft, S., & Ko?evar Glava?, N. (2020). Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. Phytother Res, 34(2), 254-269. https://doi.org/10.1002/ptr.6524

Puglia, C., & Santonocito, D. (2019). Cosmeceuticals: nanotechnology-based strategies for the delivery of phytocompounds. Current pharmaceutical design, 25(21), 2314-2322.

Putri, T., Raya, I., Natsir, H., & Mayasari, E. (2018). Chlorella sp: Extraction of fatty acid by using avocado oil as solvent and its application as an anti-aging cream. Journal of Physics: Conference Series,

Rafique, S., & Akhtar, N. (2018). Phytochemical analysis and antioxidant activity of Persia americana and Actinidia deliciosa fruit extracts by DPPH method. Biomed. Res, 29(12), 2459-2464.

Rodríguez-Carpena, J.-G., Morcuende, D., Andrade, M.-J., Kylli, P., & Estévez, M. (2011). Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. Journal of agricultural and food chemistry, 59(10), 5625-5635.

Romes, N. B., Abdul Wahab, R., & Abdul Hamid, M. (2021). The role of bioactive phytoconstituents-loaded nanoemulsions for skin improvement: a review. Biotechnology & Biotechnological Equipment, 35(1), 711-730. https://doi.org/10.1080/13102818.2021.1915869

Rosenblat, G., Meretski, S., Segal, J., Tarshis, M., Schroeder, A., Zanin-Zhorov, A., Lion, G., Ingber, A., & Hochberg, M. (2011). Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. archives of dermatological research, 303(4), 239-246.

Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno-Rojas, J. M. (2021). Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview. Foods, 10(4). https://doi.org/10.3390/foods10040839

Sharquie, K. E., Al-Hamamy, H. R., Noaimi, A. A., & Tahir, A. F. (2012). Treatment of Acne Vulgaris with 5-Alpha Avocuta Cream 2% in Comparison with Tretinion Cream 0.025%(Single Blind Comparative Study). Journal of Cosmetics, Dermatological Sciences and Applications, 2(3), 179.

Sichani, M. R. E., Farid, M., & Khorasgani, E. M. (2021). Histomorphological Examination of Skin Wound Healing Under the Effect of Avocado Oil in Wistar Rats. Acta Veterinaria Eurasia, 47(3), 121-129.

Smit, N., Vicanova, J., & Pavel, S. (2009). The hunt for natural skin whitening agents. International journal of molecular sciences, 10(12), 5326-5349.

Thiyagarasaiyar, K., Goh, B.-H., Jeon, Y.-J., & Yow, Y.-Y. (2020). Algae metabolites in cosmeceutical: An overview of current applications and challenges. Marine drugs, 18(6), 323.

Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., . . . Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med, 169(7), 467-473. https://doi.org/10.7326/m18-0850

Vinha, A. F., Barreira, S. V., Castro, A., Costa, A., & Oliveira, M. B. P. (2013). Influence of the storage conditions on the physicochemical properties, antioxidant activity and microbial flora of different tomato (Lycopersicon esculentum L.) cultivars. Journal of Agricultural Science, 5(2), 118.

Wang, W., Bostic, T. R., & Gu, L. (2010). Antioxidant capacities, procyanidins and pigments in avocados of different strains and cultivars. Food chemistry, 122(4), 1193-1198.

Yon, J.-A.-L., Lee, S.-K., Keng, J.-W., Chow, S.-C., Liew, K.-B., Teo, S.-S., Shaik Mossadeq, W. M., Marriott, P. J., Akowuah, G. A., Ming, L. C., Goh, B. H., & Chew, Y.-L. (2023). Cassia alata (Linnaeus) Roxburgh for Skin: Natural Remedies for Atopic Dermatitis in Asia and Their Pharmacological Activities. Cosmetics, 10(1), 5. https://www.mdpi.com/2079-9284/10/1/5

Züge, L. C. B., Maieves, H. A., Silveira, J. L. M., da Silva, V. R., & de Paula Scheer, A. (2017). Use of avocado phospholipids as emulsifier. LWT-Food Science and Technology, 79, 42-51.