Layer-By-Layer Coating of Sesame Oil in Alginate-Chitosan Beads for Enteric Coating and Sustained Release

Somaia  Abueta; Hazrina Ab Hadi; Abd Almonem  Doolaanea; Abdullah Mohammed  Aloqyli

doi:10.31436/jop.v4i1.248

Authors

Somaia Abueta Dermatopharmaceutics Research Group, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
Hazrina Ab Hadi Dermatopharmaceutics Research Group, Kulliyyah Of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
Abd Almonem Doolaanea Research and Development, Sabrena Experience, 1500 Dragon Street, Suite 160, Dallas, Texas 75207, USA.
Abdullah Mohammed Aloqyli Department of Histology, Faculty of Medicine, Batterjee Medical College, Jeddah, Saudi Arabia.

DOI:

https://doi.org/10.31436/jop.v4i1.248

Keywords:

Enteric coating, Sustained release, Layer-by-Layer, Sesame oil, Chitosan, Alginate

Abstract

Introduction: Medical uses of alginate-chitosan beads have been growing widely in recent years due to their varied applications in pharmaceutical and biomedical technology. Moreover, a variety of research have used drug encapsulation in the alginate-chitosan matrix to facilitate the enteric coating and sustained release of therapeutic molecules. Sesame oil has various medical applications as it contains a significant amount of lignans, which enhance its antioxidant function and anti-inflammatory effects for external or internal medical uses. In addition, it has contributed to the treatment of several inflammatory bowel diseases. Layer-by-layer assembly provides an effective coating for drugs, improving the oil instability in the gastric media, preventing drug leakage, and elongating the release time for sesame oil. This study aims to encapsulate sesame oil in alginate-chitosan beads and to optimize the formulation for enteric coating.

Method: Consuming sesame oil directly will not enable gastrointestinal tract to obtain the desired quantity of active ingredients in the oil due to the early degradation of oil. Therefore, the beads were prepared by using the external gelation method with layer-by-layer technique to provide multicoated layers. To illustrate, the usage of layer-by-layer assembly for the encapsulated alginate-sesame oil beads was accomplished by alginate and chitosan polysaccharides. A stability test was held to ensure the formulation stability during the study. In addition, the beads were characterized for particle size, roundness, and in-vitro drug release in different simulated buffers.

Results: This study revealed that the layer-by-layer approach is a viable method to obtain a sesame oil alginate-chitosan bead formulation for enteric coating and sustained release. Formulation coated layer-by-layer provided a successful pass of the stomach system whereas 68% of cumulative drug release occurred in the intestine within 5 h. To illustrate, during 135 min uncoated beads showed a cumulative drug release of 65% while the same percentage was achieved in 255 min for coated beads.

Conclusion: Sesame oil alginate-chitosan beads could be introduced as a promising carrier for encapsulating essential oils with favourable features.

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