TY - JOUR AU - Ibrahim, Mior Azrizal AU - Berahim, Zurairah AU - Ahmad, Azlina AU - Taib, Haslina PY - 2021/07/31 Y2 - 2024/03/29 TI - The effect of locally delivered Tualang honey on healing of periodontal tissues during non-surgical periodontal therapy JF - IIUM Journal of Orofacial and Health Sciences JA - IJOHS VL - 2 IS - 2 SE - Original Article DO - 10.31436/ijohs.v2i2.65 UR - https://journals.iium.edu.my/ktn/index.php/ijohs/article/view/65 SP - 16-26 AB - <p>Honey is a sweet, viscous natural substance made from flower nectar by bees. Honey has been used not only as a nutritional source but also for wound healing and to reduce tissue inflammation. Nevertheless, the use of honey in the treatment of periodontitis is not well established. This study aimed to evaluate the effect of locally delivered Tualang honey on periodontal tissue healing by a randomized controlled split-mouth clinical trial involving 20 chronic periodontitis patients with a periodontal pocket depth of ? 5 mm. Each site was randomly treated either by scaling and root debridement alone (Control Group) or scaling and root debridement with locally delivered Tualang honey (Test Group). Assessment of probing pocket depth (PPD) and clinical attachment level (CAL) was recorded at baseline and after 6 weeks interval. Gingival crevicular fluid samples were collected from treated pockets at baseline and along with periodontal reassessment to evaluate the level of Matrix Metalloproteinase 8 (MMP-8) and Osteoprotegerin (OPG). Data were analysed by using Wilcoxon Signed Rank Test and Paired Sample t-Test. PPD and CAL were significantly improved after the 6 weeks review (P=0.001) in both groups. However, there was no significant difference in the changes of the PPD, CAL, MMP-8 and OPG levels after the 6 weeks review and in between the groups. In conclusion, within the limitations of this study, the effect of locally delivered Tualang honey on periodontal tissue healing is not evident. Nevertheless, all pockets achieved good periodontal healing.</p><p> </p> ER -