TY - JOUR AU - K, Abdul Razak AU - A, Mariam AU - S, Amirin AU - A, Mohd Zaini PY - 2010/06/01 Y2 - 2024/03/28 TI - Assessment on Functionality and Viability of β cells Following Repetitive Dosage Administration of Ethanolic Extracts of Andrographis paniculata on Streptozotocin-induced Diabetic Rats JF - IIUM Medical Journal Malaysia JA - imjm VL - 9 IS - 1 SE - Original Articles DO - 10.31436/imjm.v9i1.737 UR - https://journals.iium.edu.my/kom/index.php/imjm/article/view/737 SP - AB - <p>Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment. Results: The results showed that there was a significant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated groups gave a significant reduction (p&lt;0.05). Immunohistochemical assessments revealed that all extract groups and metformin-treated were significantly increased in the population of β cells (p&lt;0.01). Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level.</p> ER -