@article{K_S_G_A_S_2011, title={Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children}, volume={10}, url={https://journals.iium.edu.my/kom/index.php/imjm/article/view/703}, DOI={10.31436/imjm.v10i1.703}, abstractNote={<p>Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity (AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this condition.</p>}, number={1}, journal={IIUM Medical Journal Malaysia}, author={K, Ruchi and S, Anil Kumar and G, Sunil and A, Bashir and S, Prabhat}, year={2011}, month={Jun.} }