Optimal dose of granisetron in reducing the incidence and severity of pruritus post intrathecal morphine for Caesarean deliveries: Granisetron for pruritus post intrathecal morphine

Chong Ling Tong; Joanna Ooi; Esa  Kamaruzaman

doi:10.31436/imjm.v21i2.1655

Optimal dose of granisetron in reducing the incidence and severity of pruritus post intrathecal morphine for Caesarean deliveries

Granisetron for pruritus post intrathecal morphine

Authors

Chong Ling Tong Universiti Kebangsaan Malaysia Medical Centre
Joanna Ooi Universiti Kebangsaan Malaysia Medical Centre
Esa Kamaruzaman Avisena Specialist Hospital, Selangor, Malaysia

DOI:

https://doi.org/10.31436/imjm.v21i2.1655

Keywords:

Granisetron, pruritus, intrathecal morphine, Caesarean section

Abstract

INTRODUCTION: Pruritus is one of the common side effects observed after intrathecal morphine (ITM) especially among parturients. Granisetron, a 5-HT₃ antagonist has been shown to reduce this side effect. MATERIAL AND METHODS: This prospective randomised double-blind control trial compared two different doses of granisetron for anti-pruritic efficacy. One hundred and twenty parturients with a singleton uncomplicated pregnancy undergoing Caesarean section received spinal anaesthesia with ITM 0.1 mg. After the delivery of baby, they were randomised to receive either granisetron 1 mg (Group 1) or 3 mg (Group 2). The severity of pruritus was assessed within 24 hours at different intervals and were graded. RESULTS: Patients demographic and clinical characteristics were comparable between the two groups. The incidence for pruritus between Group 1 and 2 was 63.3% and 65.0% respectively with p value of 0.849 with a proportion of difference of 1.7%. Similarly, the severity of pruritus at different intervals, the need for rescue treatment and patient satisfaction for both groups were not statistically significant. CONCLUSION: Granisetron 1mg is effective when given as prophylaxis in reducing the incidence, severity and the need for rescue treatment in ITM-induced pruritus among Caesarean delivery patients.

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Published

2022-04-01

How to Cite

Tong, C. L., Ooi, J., & Kamaruzaman, E. . (2022). Optimal dose of granisetron in reducing the incidence and severity of pruritus post intrathecal morphine for Caesarean deliveries: Granisetron for pruritus post intrathecal morphine. IIUM Medical Journal Malaysia, 21(2). https://doi.org/10.31436/imjm.v21i2.1655

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Issue

Vol. 21 No. 2 (2022): IIUM Medical Journal Malaysia - April 2022

Section

Original Articles

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