THE ISLAMIC ETHICS OF MITOCHONDRIA TRANSPLANTATION
ABSTRACT: Biotechnology has opened a new chapter with the advent of mitochondria transplantation for cell-based therapy. Mitochondrial transplantation was successfully led to birth; however, cytoplasmic transplantation has caused apprehension, since the mixing of human ooplasm from two different maternal sources may generate mitochondrial DNA (mtDNA) heteroplasmy in the offspring. Islamic legal verdicts on human cloning and somatic cell transfer have been overweighing explicit as to its prohibition, due to the change of creation, mixing of lineage and other evaluations. Is mitochondria transplantation equivalent to human cloning in that genetic information is proliferated and does it, therefore, take the same legal rule? Are there possible benefits (masalih) for medical treatment that may render mitochondria transplantation permissible, or are possible harms (mafasid) overweighing? Or is it a completely different procedure, taking a different rule? The paper will investigate into these questions and discuss the dimensions of Islamic ethics on the issue.
 Baylis, Francoise: The ethics of creating children with three genetic parents, Reproductive Medicine Online (2013) 26, 531-534.
 Elliott, R.L., X.P. Jiang, J.F. Head: Mitochondria Organelle Transplantation: Introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity. Breast Cancer Research and Treatment (2012), 136:347-354.
 Elliott, R.L., X.P. Jiang, J.F. Head: Mitochondria Organelle Transplantation: The Mitochondrion, “An Intracellular Organelle for Cell-Based Therapy” Opinion Commentary. International Journal of Applied Science and Technology, vol.4, no.5, October 2014, p.158-162.
 New Scientist: Three-parent babies: It’s more messy than we thought. 17 September 2014, https://www.newscientist.com/article/mg22329871-600-three-parent-babies-its-more-messy-than-we-thought/
 IMANA (Islamic Medical association of North America), 1967. Islamic Medical Ethics (Publication 2), Section 4: F Organ Donation and Transplantation. Available at: https://c.ymcdn.com/sites/www.imana.org/resource/resmgr/Files/Publication2.pdf
 Al-Suyūṭī, al-Ashbāh wa l-naẓā’ir fī qawācid wa furūc fiqh al-shāficiyyah, Beirut, Dar al-Kutub al-‘Ilmiyyah, 2007
 Barritt, Jason A., Carol A. Brenner, Henry E. Matter and Jacques Cohen: Mitochondria in human offspring derived from ooplasmic transplantation. Human Reproduction vol.16, pp.513-516, 2001.
 Gorman, Granine S, et al: Mitochondrial Donation – How many women could benefit? The New England Journal of Medicine, 2015, 372:885-887
 Baylis: The truth about mitochondrial replacement, Impact ethics, February 23, 2015
 Stammers, Trevor: The ethics of mitochondrial transfer. Lecture was given at the First International Bioethics Conference, Sultan Qaboos University, Muscat, Oman, March 2015.
 Al-Ghazālī, Abū Ḥāmid: Al-Musṭaṣfā fī cilm al-uṣūl. Beirut, 1997.
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